摘要
整合素连接激酶(ILK)是一种存在于胞浆内的丝/苏氨酸蛋白激酶。它作为细胞内的一种转录因子,能与细胞的多种跨膜受体相互作用,调节正常细胞的各种功能,如促进细胞的增殖、转化、迁移和一些蛋白的表达,能够促进由整合素介导的细胞外基质的聚集,降低细胞与细胞之间的黏附。其中有些生物学效应与糖尿病肾病有着密切的联系,如早期的肾小球硬化、肾间质纤维化以及肾小管上皮细胞的间充质转化。因此它有可能为糖尿病肾病的治疗提供新的思路和方法。
Integrin-linked kinase is a serine/threonine protein kinase in cytochylema. As one of the transcriptional factor in cells, It can interact with different types of transmembrane receptors and thus regulate common cellular processes including cell proliferation, differentiation, migration and protein expression, which can promote the aggregation of integrin mediated extracellular matrix and lower the adhesion between cellular. Some of the effects are closely associated with the diabetic nephropathy. such as diabetic glomerulosclerests, interstitial fibrosis and the tubular EMT in the early stage,which may supply the new ways and methods for the treatment of the diabetic nephropathy.
出处
《医学综述》
2006年第24期1496-1498,共3页
Medical Recapitulate
