摘要
目的:观察氯吡格雷在急性冠状动脉综合征(ACS)中的抗炎作用。方法:入选健康对照组30例、稳定型心绞痛(SAP)组40例、ACS患者66例,后者按照治疗方案不同随机、单盲分为氯吡格雷加阿司匹林组(A组)和阿司匹林(B组),观察疗程1周。所有受检者测定入院时血浆高敏C反应蛋白(hs-CRP)和P选择素(Ps)水平,ACS患者治疗1周后复查hs-CRP和Ps。观察各组hs-CRP和Ps的基线状态及治疗后变化情况。结果:药物干预前ACSA、B组患者hs-CRP和Ps较SAP组和健康对照组明显升高(P<0.01)。而SAP组与健康对照组之间,A组和B组之间hs-CRP和Ps差异无统计学意义(P>0.05),干预1周后A组比B组hsCRP和Ps显著降低(P<0.01)。结论:ACS存在明显的炎症过程;氯吡格雷可以下调ACS患者的炎症因子,具有抗炎作用。
Objective： To observe whether clopidogrel has an anti-inflammatory action in patients with acute coronary syndrome（ACS）. Method： Thirty healthy control people and 106 patients with coronary atherosclerotic heart disease included 40 patients with stable angina pectoris and 66 patients with ACS were randomly assigned into group A and B to receive combination of clopidogrel and aspirin （n=33） or aspirin alone （n=33） for 7 days. All patients had measurements of high-sensitivity C-reactive protein （hsCRP） concentration and P-selection （Ps） level at base line. The changes of hsCRP and Ps in patients with ACS were assessed after 7 days. Result： The hsCRP concentration and Ps level in patients with ACS were significantly higher than those in patients with stable angina pectoris and healthy control at base line （P〈0.01）. Combination of clopidogrel and aspirin significantly reduced plasma concentration of hsCRP and platelet Ps expression after 7 days compared with aspirin alone（P〈0.01）. Conclusion ：Inflammatory processes have an important role in ACS. Our results indicate that clopidogrel has beneficial effects on down regulating inflammatory processes except for inhibiting platelet activation.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2006年第12期716-718,共3页
Journal of Clinical Cardiology
基金
武汉市科技攻关课题[No:武卫(2004)241]
