摘要
目的 :探讨炎症标记物与冠心病的关系及临床意义。方法 :选择健康体检者 (正常对照组 ) 30例、稳定型心绞痛 (SAP组 )患者 2 0例、不稳定型心绞痛 (UAP)患者 2 5例和急性心肌梗死 (AMI)患者 30例 ,分别测定血清中C 反应蛋白 (CRP)、白细胞介素 6 (IL 6 )和肿瘤坏死因子 α(TNF α)的浓度。结果 :①SAP、UAP、AMI与正常对照组比较 ,血清中CRP、IL 6、TNF α均显著增高 ,差异均具有统计学意义 (均P <0 .0 1) ;②UAP与SAP比较 ,血清中CRP、TNF α均显著增高 (P <0 .0 1) ,但与IL 6比较差异无统计学意义 ;③AMI与SAP比较 ,血清中CRP、IL 6、TNF α均显著增高 ,差异均具有统计学意义 (P <0 .0 1) ;④AMI与UAP比较 ,血清中CRP、IL 6、TNF α均显著增高 ,差异均具有统计学意义 (P <0 .0 5 ) ;⑤血清中CRP、IL 6、TNF α在AMI发病的 72h以内有明显动态变化。结论 :炎症参与了冠心病的发病过程 ,血清中炎症因子水平的高低与冠心病的严重程度有关 ,AMI时炎症因子的动态演变可以作为病情稳定性的指标 ,对判断病情和预后具有临床价值。
Objective:To investigate the relation of inflammation markers to Coronary heart disease (CHD) and the clinical significance by observing the changes of CRP, IL-6, TNF-α during agina pectoris and acute myocardial infarction.Method:All persons were divided into control group , stable agina pectoris group(SAP) , unstable agina pectoris group(UAP) and acute myocardium infarction group(AMI) , The concentration of CRP was determined by scatter turbidimetry , and the concentration of IL-6 and TNF-α by ELISA.Result:①In SAP, UAP and AMI groups, the levels of CRP, IL-6 and TNF-α were significantly(P< 0.01) increased compared with that in Control group; ②Compared with SAP group, the levels of CRP and TNF-α in UAP group increased (P< 0.01); ③In AMI group, the levels of CRP, IL-6 and TNF-α were higher (P< 0.01), (P< 0.05); ④The levels tham that in SAP and UAP group of CRP, IL-6 and TNF-α significantly inorease during 72 h in group AMI.Conclusion:The levels of inflammation factors in serum are related to the seropisemss of CHD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2004年第7期398-400,共3页
Journal of Clinical Cardiology
