摘要
目的:在血清学水平上探讨C-反应蛋白(CRP)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)与急性冠状动脉综合征(ACS)的关系,评价CRP、MMP-2、MMP-9水平作为ACS的血清学指标的意义。方法:分别利用酶联免疫吸附法及散射比浊法对30例急性冠状动脉综合征(ACS)组,30例稳定型心绞痛(SAP)组,30例非冠心病者(正常对照组)外周血清CRP、MMP-2、MMP-9水平进行测定。结果:ACS组,SAP组血清CRP、MMP-2、MMP-9水平明显高于正常对照组,差异具有统计学意义(P<0.01),ACS组血清CRP、MMP-2、MMP-9水平明显高于SAP组,差异具有统计学意义(P<0.01)。结论:血清CRP、MMP-2、MMP-9水平可反映斑块稳定性,可作为检测ACS的血清学指标。
Objective：To investigate the relationship between serum levels of C -respective protein （CRP） and matrix metalloproteinase -2 （MMP- 2） and matrix metalloproteinase- 9 and acute coronary syndrome （ACS） and its significance as serum target of ACS. Methods：The levels of CRP and MMP -2 and 9 in peripheral serum of 30 ACS patients, stable angina peetoris （SAP） patients and 30 without coronary heart disease patients as control were measured, respectively by enzyme - linked immunoassay （ELISA） and scatter rateturbidity. Results： The serum levels of CRP and MMP - 2 and 9 in ACS group, SAP group were higher than that in without coronary heart disease group . The levels of CRP and MMP -2 and 9 in ACS group were higher than that in SAP group. There was a positive correlation between the levels of CRP and MMP -2 and 9. Conclusions： Elevation of serum levels of CRP and MMP - 2 and 9 are related with unstable plaque . It can be used as a serum target to judge ACS.
出处
《中国民康医学》
2007年第3期88-89,106,共3页
Medical Journal of Chinese People’s Health
