摘要
目的初步探讨全身18氟[18F]-FDGPET/CT在原发灶不明的颈部转移癌中的应用价值。方法对42例原发灶不明的颈部转移癌患者行全身18F-FDGPET/CT检查,分别对单独PET图像、单独CT图像及PET/CT融合图像进行判读,所得结果与病理和/或随访结论比较。结果PET/CT对原发灶检出率优于单独PET及单独CT(灵敏度分别为59.5%(25/42)、35.7%(15/42)、及23.8%(10/42),χ2值分别为8.100及13.067,P<0.01,均有显著统计学差异)。28.6%患者(12/42)经PET/CT检查后发现分期改变(包括4例未找到原发灶患者)。在29例已行颈部肿块切除病例中,有5例局部仍可见异常高代谢灶,提示肿瘤残余。PET/CT、单独PET及单独CT假阳性率分别为4.8%(2/42)、16.7%(7/42)及9.5%(4/42)。结论18F-FDGPET/CT全身显像对于寻找原发灶不明的颈部转移癌患者的原发灶、了解肿瘤生物学特性及全身侵犯情况有重要的临床价值,有利于临床及时制定或调整治疗方案。
Objective To retrospectively evaluate whole body ^18F-FDG PET/CT in depicting the primary lesion in cervical metastatic carcinoma of unknown primary site (CCUP). Methods Forty-two CCUP patients were included and underwent whole body ^18F-FDG PET/CT imaging to search the primary lesion. A radiologist and a nuclear medicine specialist performed blinded interpretation of PET alone, CT alone and dual-modality PET/CT imaging. Results The detection efficacy of dual-modality PET/CT was higher than PET alone and CT alone. The sensitivity was 59. 5%(25/42), 35.7%(15/42) and 23.8%(10/42) respectively. Statistical results showed the sensitivity of dual-modality PET/CT was higher than PET alone and CT alone (χ^2 value was 8. 100 and 13. 067, P〈0.01). The staging evaluation of 12 patients (28.6%, 12/42) was changed after whole body ^18F-FDG PET/CT imaging (including 4 patients with no primary lesion found). There were still 5 hypermetabolism lesions in the 29 patients who had been undergone completely local lesion ablation. The false positive rate (FPR) of dual-modality PET/CT, PET alone and CT alone is 4.8%(2/42), 16.7%(7/42) and 9.5%(4/42) respectively. Conclusion Whole body ^18F-FDG PET/CT may be of relatively higher value in identifying the primary tumor of CCUP patients compared with conventional imaging methods. It also may reveal tumor biology characteristics and display tumor involvement extent.
出处
《中国医学影像技术》
CSCD
北大核心
2006年第11期1745-1748,共4页
Chinese Journal of Medical Imaging Technology