摘要
目的探讨^18F-脱氧葡萄糖（FDG）PET／CT全身显像在原发灶不明转移癌（CUP）诊断中的临床应用价值。方法回顾性分析2006年1月至2007年6月2589例^18F—FDG PET／CT显像患者中169例CUP患者的显像结果，通过分析病历记录、病理检查结果及临床随访确定最终原发灶诊断结果。结果169例CUP患者中19例失访，150例有完整资料。70例成功探测到原发灶，总检出率为46．7％（70／150），其中52例得到病理检查证实，18例为临床诊断；肺癌38例，占54．3％，鼻咽癌8例，占11．4％，消化系统肿瘤13例，占18．6％，其他肿瘤11例，占15．7％。3例临床怀疑转移瘤，^18F-FDG PET／CT未见明显恶性征象，经随访证实为良性病变。6例PET／CT诊断错误。15例患者没有确诊。56例未探测到原发灶，其中3例在随访过程中得到确诊，分别为鼻咽癌、膀胱癌、食管癌各1例。结论^18F—FDG PET／CT全身显像对诊断CUP具有重要临床价值。
Objective Carcinoma of unknown primary （CUP） is not uncommon in usual clinical settings. They are, by definition, those eases with clinically suspected primary malignancy but not revealed by conventional investigation. The aim of this study was to investigate the efficacy of whole-body ^18F-fluorodeoxyglueose （FDG） PET/CT in deteeting a primary neoplasm for these patients. Methods A totle of 150 patients with retrievable reeords from 169 CUP patients were selected within a group of consecutive 2589 patients from Jan. 2006 to Jun. 2007. All cases underwent whole-body FDG PET/CT sean. The final diagnoses were confirmed by pathologic results, other imaging modalities or clinical follow-up. Results Among 150 patients, primary tumor sites were successfully detected by whole-body ^18 F-FDG PET/CT scan in 70 cases （46.7%）, of which 52 were pathologically confirmed and 18 by clinical follow-up. And 38 eases （54. 3% ） were lung cancer, 8 （ 11.4% ） were nasopharyngeal carcinoma, 13 （ 18.6% ） in digestive system, and 11 （15.7%） in other systems. Three clinically suspected CUP eases with negative ^18F-FDG PET/ CT were subsequently confirmed of benign processes by clinical follow-up. Six patients were wrongly diagnosed by ^18F-FDG PET/CT, and 15 patients did not have a confirmed diagnosis by the end of research. The primary cause of malignancy after lSF-FDG PET/CT remained obscure in 56 patients, only 3 of whom be- came known during the course of clinical follow-up （ nasopharyngeal bladder and esophageal carcinoma）. Conclusion lS F-FDG PET/CT whole-body imaging plays an important role in patients with metastatic CUP
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2008年第6期385-388,共4页
Chinese Journal of Nuclear Medicine
