摘要
目的研究斑蝥素对人肺癌A549细胞增殖的抑制作用和机制。方法采用MTT法检测斑蝥素对A549细胞增殖的抑制作用;流式细胞仪分析A549细胞周期及斑蝥素对细胞周期的影响。结果斑蝥素对A549细胞的增殖有抑制作用;其抑制作用机制为使A549细胞周期出现明显的G2/M期阻滞。结论斑蝥素对人肺癌A549细胞的增殖有抑制作用。
Objective To investigate the inhibition effect of cantharidin on the proliferation of human being carcinoma A549 cell. Methods MTT assay was used to determine the proliferation inhibition by cantharidin to A549 cell. FACS can were applied to detect the change of cell cycle. Results Cantharidin inhibited the proliferation of A549 cell, and the mechanism of inhibitory action is to make A549 cell cycle hindered at G2/ M.Conclusions Cantharidin has the inhibition effect to the proliferation of human being carcinoma A549 cell.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2006年第9期598-601,共4页
Journal of Shenyang Pharmaceutical University
关键词
斑蝥素
抑制作用
人肺癌A549细胞
cantharidin（CTD）
inhibitory action
human lung cancer cell A549
