摘要
脆性组氨酸三联体(FHIT)基因是一个候选抑癌基因,其抑癌作用可能通过诱导凋亡实现。在许多肿瘤特别是环境致癌物引起的肿瘤中常可发现FHIT基因的异常改变。胃癌是和环境致癌物密切相关的肿瘤,此文拟就FHIT基因与胃癌的发生、发展、转移、治疗等几方面进行综述。
The FHIT gene has been suggested to be a candidate tumor suppressor gene by inducing apoptosis. It is altered in a large number of human cancers, especially those associated with environmental carcinogenic agents. Since gastric cancer is closely associated with environmental carcinogenic agents,we review the relation between FHIT gene with occurrence,development, metastasis and treatment of gastric cancer in this article.
出处
《国际消化病杂志》
CAS
2006年第4期251-253,共3页
International Journal of Digestive Diseases
关键词
FHIT基因
胃癌
凋亡
FHIT gene
Gastric cancer
Apoptosis
