摘要
目的:通过观察结直肠癌患者血清胆碱酯酶(CHE)活性的变化,探讨血清CHE活性与结直肠癌的关系,并分析其临床意义。方法:采用速率法检测71例结直肠癌患者手术前后血清CHE活性,并与48例非结直肠癌的肠道疾病患者和40位健康体检者比较。结果:结直肠癌组血清CHE活性均较肠道疾病组和健康组明显降低,P=0·000,其中DukesC、D期患者尤为明显;术后4周血清CHE活性恢复至正常水平,与术前CHE活性相比差异有统计学意义,P=0·000。结论:血清CHE活性测定可作为结直肠癌的标志物之一,对结直肠癌患者的病情监测和预后判断具有重要的临床意义。
OBJECTIVE： To study the alternation and significance of serum cholinesterase（CHE） in patients with colorectal cancer. METHODS： The activities of CHE were detected pre-operatively and post-operatively with the velocity technique in 71 patients with colorectal cancer, and compared with those in 48 colorectal disease patients without cancer and 40 healthy persons. RESULTS.. The activities of CHE in patients with colorectal cancer, especially in Dukes C and D patients, were much lower than those in the control groups, and recovered to the normal level post-operatively. CONCLUSIONS.. As the marker of colorectal cancer, the CHE has significantly clinical value on monitoring tumor progression and evaluating prognosis in colorectal cancer.
出处
《中华肿瘤防治杂志》
CAS
2006年第14期1080-1081,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
结直肠肿瘤
胆碱酯酶类
预后
colorectal cancer
cholinesterases
prognosis
