摘要
目的探讨血清胆碱酯酶(ChE)对晚期肠癌患者化疗疗效及转归的预测价值。方法选取50例晚期肠癌患者,检测其每次化疗前血清ChE水平,并随访2年。结果将患者初次化疗2个周期后与化疗前的血清ChE水平进行比较:病灶稳定组与病灶缩小组均无统计学差异(P>0.05);病灶增大组下降(P<0.01)。存活组观察终点前血清ChE水平较初次化疗前降低的有16例(53.3%),少于死亡组的20例(100%)(χ~2=12.96,P<0.01)。结论血清ChE水平对于晚期肠癌患者的化疗疗效以及转归的预测具有一定的价值。
Objective To investigate the value of serum cholinesterase（ChE）in predicting the chemotherapeutic effect and prognosis of the patients with advanced colorectal cancer.Methods Serum ChE was measured before each chemotherapy in 50 patients with advanced colorectal cancer,who were followed up for two years.Results Serum ChE levels after the first two cycles of chemotherapy were compared to those before primary chemotherapy,which showed that there were no significant differences in serum ChE levels between the cases with stable lesion and those with lesion reduction（P〈0.05）,but serum ChE level was lower in the cases with lesion enlargement than that in those without lesion enlargement（P〈0.01）.The percentage of cases with decreased serum ChE levels before the end points of chemotherapy was higher in death group than that in survival group（100% vs.53.3%）（P〈0.01）.Conclusion Serum levels of ChE have a considerable value in predicting the chemotherapeutic effect and prognosis of the patients with advanced colorectal cancer.
作者
蒋敏
徐建忠
徐珍
倪玲娜
刘永
JIANG Min;XU Jianzhong;XU Zhen(Department of Oncology,Affiliated Changzhou Tumor Hospital,Soochow University,Changzhou 213000,CHINA)
出处
《江苏医药》
CAS
2018年第7期789-791,共3页
Jiangsu Medical Journal
关键词
胆碱酯酶
结直肠癌
化疗
Cholinesterase
Colorectal cancer
Chemotherapy
