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血清CA125,LDH,β_2-MG在非霍奇金淋巴瘤诊断治疗中的意义 被引量:13

The clinical significance of the serum CA125, LDH, β_2-MG measuring in the diagnosis and treatment of non-Hodgkin lymphoma
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摘要 目的探讨血清CA125,LDH,β2-MG在非霍奇金淋巴瘤(NHL)诊断、治疗中的意义。方法50例NHL患者,采用放射免疫学方法检测CA125及β2-MG,酶法检测LDH。结果NHL患者血清CA125,LDH,β2-MG的升高与分期、分组、骨髓浸润、化疗效果、疾病的范围及恶性程度有关。结论血清CA125,LDH,β2-MG作为NHL患者诊断、临床分期、是否骨髓浸润、疗效判定及预后的辅助指标。 Objective To explore the clinical significance of the serum CA125, lactic dehydrogenase (LDH), β2-micruglobulin (β2-MG) measuring in the diagnosis and treatment of non-Hodgkin lymphoma. Methods 50 cases with NHL, CA125 and β2-MG are measured by radioimmunoassay. LDH is measured by enzyme method. Results The increase of serum CA125, LDH, β2-MG in patients with NHL has relation to clinical phase, group, bone marrow infiltration and chemotherapy result, NHL infiltration and malignant stage. Conclusion The level of serum CA125, LDH, β2-MG can be taked as an auxiliary clinical index to diagnose, classify the phase, with or without existence of NHL cells in bone marrow, evaluation the effectiveness of treatment and prognosis in the NHL patients, and have important clinical significance.
出处 《白血病.淋巴瘤》 CAS 2006年第2期113-114,共2页 Journal of Leukemia & Lymphoma
关键词 CA125 LDH Β2-MG 非霍奇金淋巴瘤 CA125 Lactic dehydrugenase β2-MG non-Hodgkin lymphoma
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参考文献5

  • 1Lazzarino M,Orlandi E,Klersy C,et al.Serum CA125 is of clinical value in the staging and follow-up of patients with non-Hodgkin's Lymphoma[J].Cancer,1998,82(5):576-583. 被引量:1
  • 2归薇,焦士兰,赵志强,麦羡霞,张巧花.非霍奇金淋巴瘤患者血清和肿瘤组织CA125表达的初步研究[J].中华血液学杂志,2005,26(4):248-249. 被引量:16
  • 3Benboubker L,Valat C,Linassier C,et al.A new serologic index for low-grade non-Hodgkin's lymphoma based on initial CA125 and LDH serum levels[J].Ann Oncol,2000,11(8):1485-1491. 被引量:1
  • 4Zacharos I D,Efstathiou S P,Petreli E,et al.The prognostic significance of CA125 in patients with non-Hodgkin's lymphoma[J].Eur J Haematol,2002,69(10):221-226. 被引量:1
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二级参考文献5

  • 1Lazzarino M,Orlandi E,Klersy C,et al. Serum CA125 is of clinical value in the staging and follow-up of patients with non-Hodgin' s lymphoma :correlation with tumor parameters and disease activity. Cancer, 1998,82:576-582. 被引量:1
  • 2Benboubker L,Valat C, Linassier C, et al . A new serologic index for low-grade non-Hodgkin' s lymphoma based on initial CA125 and LDH serum levels. Ann Oncol,2000,11:1485-1491. 被引量:1
  • 3Zacharos ID, Efstathiou SP, Petreli E, et al. The prognostic significance of CA125 in patients with non-Hodgkin' s lymphoma. Eur J Haematol, 2002,69: 221-226. 被引量:1
  • 4Vlasveld LT, Ermens AA, Sonnenberng AA, et al. Elevated serum CA125 concentrations due to expression by a diffuse large B-cell lymphoma. Ann Clin Biochem, 2000,37:545-548. 被引量:1
  • 5Kubonishi I, Bandobashi K, Murata N, et al. High serum leves of CA125 and interleukin 6 in a patient with Ki-1 lymphoma. Br J Haematol, 1997,98:450-452. 被引量:1

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