摘要
目的研究倍他司汀对荷瘤肝癌小鼠生存时间及肉瘤瘤重的影响。方法采用小鼠移植性肿瘤肝癌H22、肉瘤S180的体内试验方法,以环磷酰胺为阳性对照药,观察倍他司汀不同剂量组对荷瘤肝癌H22小鼠生存天数、生命延长率及荷瘤S180小鼠瘤重、抑瘤率、胸腺和脾脏系数的影响。结果6.67mg/kg、13.33mg/kg、26.67mg/kg倍他司汀组的肝癌H22小鼠生命延长率分别为5.48%、8.22%、16.44%,与剂量呈一定的正相关,26.67mg/kg倍他司汀组的生存天数显著延长(与生理盐水组比较,P<0.05);6.67mg/kg、13.33mg/kg、26.67mg/kg倍他司汀组的S180小鼠抑瘤率分别为6.83%、9.13%、18.05%,与剂量呈一定的正相关,26.67mg/kg倍他司汀组的S180小鼠瘤重显著减少(与生理盐水组比较,P<0.05)。结论倍他司汀对荷瘤肝癌H22小鼠有延长生存时间的作用,对S180肉瘤有抑制作用。
Objective To study the effects of betahistine on survival time in mice with hepatoma and turmor weight in mice with sarcoma.Methods Hepatorna H22 and sarcoma S180 were transplanted to mice and the effects of betahistine were observed.Results The mice bearing H22 were treated with 6.67mg/kg, 13.33mg/kg or 26.67mg/kg betahistine for 7 days, the life prolongation rate was 5.48% ,8.22% and 16.44% ,respectively,which was positively correlated with the dosage. The survival time of 26.67mg/kg betahistine group was significantly increased compared with the control group（P〈0.05） .The mice bearing S180 were treated with 6.67mg/kg, 13.33mg/kg or 26.67mg/kg Betahistine for 7 days and the tumor weight was decreased , the inhibition rate was 6.83%, 9.13% and 18.05 %, respectively, which was positivdy correlated with the dosage. The turmor weight of 26.67mg/kg betahistine group was significantly decreased compared with the control group（ P 〈0.05）. Conclusion The results suggest that betahistine can prolong the survival time in mice with hepatoma H22 and inhibite tumor-growth in mice with sarcoma S180.
出处
《广西医学》
CAS
2006年第6期812-814,共3页
Guangxi Medical Journal
基金
广西壮族自治区教育厅重点科研项目
国家自然科学基金资助项目(30360118)。
