摘要
作者以肉瘤Ｓ１８０小鼠为模型，经皮下注射金黄色葡萄球菌ＣｏｗａｎＩ（ＳｔａｐｈｙｌｏｃｏｃｕｓａｕｒｅｕｓＣｏｗａｎＩ，ＳＡＣ），在扫描电镜和透射电镜下，观察了ＳＡＣ体内治疗对带瘤小鼠腹腔巨噬细胞超微结构的影响。结果显示，与对照组相比，ＳＡＣ治疗后巨噬细胞体积明显增大，表面皱褶增多，有许多粗大的伪足，胞质丰富，胞质内充满大小不一的噬体，肥大细胞增多。结果提示，ＳＡＣ能使带瘤小鼠腹腔巨噬细胞明显活化，吞噬功能加强，这与其抗肿瘤机制可能有关，肥大细胞增多与其过敏反应可能有关。
The effects of subcutaneously infected Staphylococcus aureus Cowan 1(SAC) on ultrastructures of peritoneal macrophages in sarcoma 180 bearing mice were observed under scanning electron microscopy and transmission electron microscopy.The results showed that,in contrast to the control,the volume of the macrophages in SAC treated mouse group was apparently enlarged, that the surface folds of them were markedly increased and had a lot of thick pseudopodia, their cytoplasms were abundant and being filled with large or little phagosomes, and the mastocytes in this group augmented. These data suggest that the peritoneal macrophages in tumor bearing mice were remarkably activatied by SAC, and their phagocytic function significantly strengthened,which may be related to the antitumor mechanisms of SAC, and that the increase of mastocytes may be responsible to the hypersensitive reaction of SAC.
出处
《实用癌症杂志》
1997年第1期4-6,共3页
The Practical Journal of Cancer
