摘要
目的探讨应用草酸铂(L-OHP)与长春瑞滨联合方案治疗晚期食管癌患者的疗效与毒副反应。方法28例经病理学证实的晚期食管癌患者入组。L-OHP 130mg/m2加入5%葡萄糖溶液中滴注,第1天;长春瑞滨(NVB)25mg/m2,第1、8天,快速静脉滴注,随后生理盐水、激素冲洗血管;每3周为一周期,至少应用2个周期。结果获得完全缓解(CR)4例(14.3%),部分缓解(PR)18例(64.3%),稳定(SD)4例,进展(PD)2例。客观总有效率为78.6%,中位缓解期为4.7个月,中位疾病无进展时间(TTP)为4.3个月,中位生存期为7.5个月。主要毒性有骨髓抑制、消化道反应、神经毒性、静脉炎。结论草酸铂联合长春瑞滨治疗晚期食管癌疗效好,毒副反应能耐受,值得进一步研究。
Objective To study the effects and side effects of oxaliplatin（L-OHP） plus vinorelbine（NVB） in the treatment of advanced esophageal cancer. Methods Twenty - eight patients with a histologic diagnosis of advanced esophageal cancer were observed. NVB was used by 25mg/m^2 on clay 1,8, L-OHP was used by 130mg/m^2 on clay 1,21 clays as a cycle. All patients were treated at least two cycles. Results Four cases achieved complete response （CR） and 18 achieved partial response （ PR）, with an overall response rate of 78.6%. Median duration of response was 4.7 months. Median time to progression（TTP） was 4.3 months. Median duration of survival was 7.5 months. The major toxicity included bone suppression, gastrointestinal reaction, nerve toxicity and phlebitis. Conclusion Oxaliplatin plus vinorelbine is effective in treating advanced esophageal cancer patients with tolerable side reactions. It is worth studing in the future.
出处
《临床医学》
CAS
2006年第4期18-19,共2页
Clinical Medicine
关键词
晚期食管癌
化疗
草酸铂
长春瑞滨
Advanced esophageal cancer
Chemotherapy
Oxaliplatin
Vinorelbine
