摘要
目的:探讨有机锗-132对乙醇依赖所致大鼠肝损伤的拮抗作用。方法:用市售北京红星牌二锅头(含52%酒精),按5.0g/kg体重剂量连续3个月灌胃形成大鼠酒精依赖,同时给予有机锗-132,观察大鼠肝脏损伤情况,并检测血谷丙转氨酶(GPT)活性、肝组织中脂质过氧化物终末产物丙二醛(MDA)的含量变化及超氧化物歧化酶(SOD)、黄嘌呤氧化酶(XOD)和过氧化氢酶(CAT)的活性。结果:给大鼠喂饲乙醇三个月,其肝组织中的丙二醛含量与对照组比较明显升高(P<0.01),抗氧化酶SOD和CAT活性明显降低(P<0.05),XOD活性明显升高(P<0.01);酒中加锗-132能明显降低肝组织中的丙二醛含量,SOD、CAT及XOD活性亦有所恢复。结论:有机锗-132对乙醇中毒所致大鼠肝脏损伤有一定的保护作用。
Objective：To study protection of organo-germanium-132 on liver during alcoholism at rat. Methods：This study formed ethanol de pendent rats by using 52 % Erguotou[Beijing Hongxingpai）5.0 g/kg. weight ingestion for 3 months, along with feeding rat by adding organogermanium-132 in alcoholic beverages, observing state of injure on liver of the rat , and detecting GPT activity in blood,the level of malondialdehyde （ MDA） and activity of superoxide dismutase （SOD）,Xanthinoxidase （XOD） and eatalase （ CAT）. Results：Between alcoholic group and control group, the level of MDA and XOD was increased, the activities of SOD and CAT were decreased, and differences were significantly [ P 〈 0.01 ）. The level of malondiadehyde （MDA） could be decreased to add organo-germanium-132 in alcoholic beverages, the activities of SOD, CAT and XOD were also recovered. Conclusion：The study declared that organo-germanium-132 might protect liver of rat during alcoholism.
出处
《中国公共卫生管理》
2006年第2期145-146,共2页
Chinese Journal of Public Health Management
