摘要
以给药后血清中超氧化物歧化酶(SOD)活力升高率为药效指标,研究了中药复方制剂“宠康”在犬体内的药代动力学。分别采用药效法和量效法两种方法描述药物代谢动力学参数,应用药代动力学参数计算程序进行计算。结果,犬口服“宠康”后时间-SOD活力升高率(T-E)及时间-相对生物相药量(T-D')数据符合一级吸收一室模型。“宠康”的药代动力学研究结果表明,犬口服“宠康”后产生药理效应较快,达峰时间较短;口服有明显的滞后时间,药效能维持较长时间。
The pharmacokinetics of the Chinese herbal medicine compound preparation（Chongkang）was investigated in dogs by measuring the increasing percntage of the SOD activity in serum.The pharmacokinetics parameters were calculated with the pharmacokincticcs procedure by the pharmacodynamic means and dose-effect means respectively.The data of T-E and T-D＇ were both fitted to one-compartment model with one-stage absorption after oral administration.The sesult showed that Chongkang could bring efgfects relative quickly in dogs after oral administration,as well as it had a shorter TP and could maintain a loger time.
出处
《中兽医医药杂志》
2006年第2期5-8,共4页
Journal of Traditional Chinese Veterinary Medicine
