摘要
选择给药后血清中超氧化物歧化酶(SOD)活力升高率为药效学指标 ,对动物保健中药复方制剂“宠康”进行了量效关系研究。结果表明 :在给药剂量 1 .0 3 8× 1 0 3 mg/kg体重与2× 1 0 4 mg/kg体重之间 ,“宠康”对血清中 SOD活力的升高率呈现一定的量效关系。而当剂量大于 2× 1 0 4 mg/kg体重时 ,随着剂量的增大 ,SOD活力的升高率逐渐降低 ,甚至出现负增长 ,给药剂量达到 1× 1 0 5mg/kg体重时 ,SOD活力下降到 3 40 .40± 6 3 .1 8Nu/m L,显著低于空白对照组 (P<0 .0 5) ,SOD活力降低了 1 8.55% ,表现出对酶活力的抑制作用。由此可见 ,在中兽药的研究和开发中 ,确定科学合理的给药剂量 。
The relationship between the dose of oral administration of CHONGKANG and the superoxide dismutase (SOD) activity in serum was studied.The results showed that the drug had dose dependent relationship in the SOD activity in serum after oral administration of CHONGKANG,when the dose was between 1.038×10 3 mg/kg body weight and 2×10 4 mg/kg body weight.While the dose surpassed 2×10 4 mg/kg body weight,the SOD activity in serum decreased gradually ,even below the zero.while the dose increased to 1×10 5 mg/kg body weight ,SOD activity decreased to 340.40±63.18 Nu/ml that was lower than control group(P0.05) ,and the activity decreased by 18.55%,which showed the SOD activity was inhibited. Therefore,the research on the dose effect relationship is critical in the development of Chinese herbal medicine.
出处
《动物医学进展》
CSCD
2002年第6期79-81,共3页
Progress In Veterinary Medicine
关键词
兽药
中药复方制剂
“宠康”
量效关系
Chinese herbal medicine compound preparation
CHONGKANG
superoxide dismutase(SOD)
dose effect relationship
