摘要
目的:合成阿魏酸及其类似物并研究其清除1,1-二苯基苦基苯肼自由基(DPPH·)的能力。方法:不同对羟基苯甲醛衍生物和丙二酸进行Knoevenagel缩合反应,得到阿魏酸及其类似物;用体外清除DPPH·测定法检测其清除自由基的能力。结果:合成了9个化合物,其中7个为新报道化合物;在体外清除DPPH·测定中,这些化合物对DPPH·的清除率有较大差异。结论:阿魏酸及其类似物苯环上3,5位取代基可以明显地影响此类化合物清除DPPH·的能力。甲氧基和乙氧基可明显提高活性,溴次之,硝基则降低活性。
Objective：To synthesize ferulaic acid and its analogs, and exploit the ability of these compounds to scavenge free radicals. Methods： Ferulaic acid and its analogs were synthesized via a Knoevenagel condensation of different substituted 4-hydroxybenzaldehyde with maloic acid. The ability of the target compound to scavenge free radicals was measured using DPPH· system. Results： Of nine compounds newly synthesized, seven were firstly reported. Theses compounds showed different scavenging levels on DPPH· . Conclusion： 3, 5-substituted groups on benzene ring of ferulaic acid and its analogs significantly affected the scavenging levels on DPPH· . The scavenging levels were increased by methoxyl, ethoxyl or bromine substituents, but reduced by nitryl substituent on benzene ring.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2006年第6期454-458,共5页
Chinese Journal of New Drugs
