摘要
阿魏酸钠能抑制抗原诱发的过敏性休克，经阿魏酸钠预处理后的致敏血小板或抗原攻击后的血小板上清液转输到非致敏动物体内不再发生过敏性休克效应，同时抗原攻击后的化学发光和形态学改变明显受抑，提示阿魏酸钠对血小板抗原特异性活化及由此导致的过敏性休克有抑制作用。
ian Rulian(Department of
Pharmacology, Zhejiang Medical University, Hangzhou 310006)Sodium ferulate could
significantly inhibit the antigen-induced anaphylactic shock inrats. Transfusion of sensitized
platelets which were pretreated with sodium ferulate orattacked by antigen to non-immunized
rats could prevent the occurrence of anaphylacticshock. The chemiluminescence and
morphological changes of antigen-induced plateletcould also be inhibited. It is suggested that
the anti-allergy effect of sodium ferulate isclosely related to the interference of antigen-specific
platelet activation.
出处
《中药新药与临床药理》
CAS
CSCD
1994年第2期22-25,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
阿魏酸钠
免疫学
当归
血小板
休克
过敏性
大鼠
sodium ferulate/immunology, Angelica sinensis/immunology
bloodplatelets/immunology, shock, anaphylactic/drug therapy, rat
