摘要
分别以硫酚、桂醇为原料合成苯磺酰基和苯基取代的呋咱氮氧化物类NO供体,再经不同连接基团与羟基被保护的阿魏酸进行酯化反应,最后脱去保护基得两类共5个目标物,并对它们进行了体外抗Fas介导的细胞凋亡作用的研究。
Synthesized from thiophenol or cinnamic alcohol, two groups of furoxan-based NO donors （3-benzenesulfonylfuroxan and 3-phenylfuroxan） were subjected to esterification with hy- droxyl-protected ferulic acid through different linkers. Finally, two groups of target compounds were synthesized after deprotection of hydroxy group. All target compounds were tested on protecting HepG2 cells from Fas-mediating apoptosis by LDH assay.
出处
《化学试剂》
CAS
CSCD
北大核心
2008年第4期251-254,共4页
Chemical Reagents
关键词
阿魏酸
呋咱氮氧化物
合成
ferulic acid
furoxan-based NO donors
synthesis
