摘要
目的研究并制定乌索酸标准品的质量标准.方法采用定性、定量分析方法,依照<中华人民共和国药典>2000年版二部附录有关规定对乌索酸标准品各项指标进行检测.结果5批乌索酸标准品的比旋度为+63～67°([α]D 20,C 0.095,EtOH),熔点为285～287℃,灰分＜0.5%,高效液相色谱法测定乌索酸含量＞99.5%.结论各项指标均符合标准物质的相关规定,可用于乌索酸标准品的质量标准.
Objective To study and formulate the quality standards of ursolic acid standard products. Methods Different indices of standard products of ursolic acid were examined with qualitative and quantitative analyses according to the corresponding measures stipulated in the Appendix of the Chinese Pharmacopeoia （ Ⅱ ） published in 2000. Results The specific rotatory power of 5 batches of ursolic acid standard products was ＋ 63 ～ 67 ° （ [ α ]20^D,C 0.095 , EtOH） ; the melting point was 285 - 287℃ and the ash content, less than 0.5%. The content of ursolic acid in the products was up to 99.5 %, as revealed by HPLC. Conclusion All of the indices were shown to accord with the relevant prescripts for standard substances and the method can be used for the study of the quality standards of ursolic acid standard products.
出处
《医药导报》
CAS
2005年第12期1152-1154,共3页
Herald of Medicine
基金
国家"863"计划重点资助项目(基金编号:2002AA2Z3217)
