摘要
目的研究麻叶千里光S enecio cannabif olius抗菌活性成分。方法以革兰氏阳性菌金黄色葡萄球菌S taphy lococcus aureus、枯草芽孢杆菌B acillus subtilis和阴性菌大肠杆菌E scherich ia coli为受试菌,采用体外抑菌圈法追踪抗菌活性部分,利用各种色谱技术进行分离纯化,根据理化性质和谱学数据进行结构鉴定。结果从麻叶千里光中分离得到5个化合物,分别鉴定为5-羟基吡啶-2-甲酸甲酯(E-13)、6-羟基-7,7a-二氢-2-(6H)-苯骈呋喃酮(E-14)、2-(1,4-二羟基环己烷基)-乙酸(E-16)、3-羟基环己酸(E-17)、4-羟基苯甲醛(B-14)。结论它们均为从千里光属植物中首次分到。
Objective To study the antibacterial constituents of Senecio cannabifolius. Methods The antibacterial effect of all the extracts was tested in vitro with Staphylococcus aureus, Bacillus subtilis （Gram-positive bacilli）, and Escherichia coli （Gram-negative bacillus）. Chemical constituents were isolated by chromatography. Pysicocbemical characters and spectroscopic analyses were employed for their structural identification. Results Five compounds were isolated and their structures were elucidated by chemical and spectral methods as follows： methyl-5-hydroxy-2-pyridinecarboxylate （E-13）, 6-hydroxy-7, 7a-dihydro-2（6H）-benzofuranone （E-14 ）, 2-（1, 4-dihydroxycyclohexanyl）-acetic acid （E-16）, 3-hydroxy-cyclohexanecarboxylic acid （E-17）, and 4-hydroxy benzaldehyde （B-14）. Conclusion All of them are isolated from the plants of Senecio L. for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2005年第10期1447-1450,共4页
Chinese Traditional and Herbal Drugs
基金
"十五"国家重大科技专项资助项目(2003AA2Z3257)
关键词
麻叶千里光
千里光属
抗菌活性成分
Senecio cannabifolius Less.
Senecio L.
antibacterial activity
