摘要
目的:探讨白癜风患者血清中抗酪氨酸酶IgG、IgM抗体滴度与疾病活动程度的关系和意义。方法:抗酪氨酸酶IgG、IgM抗体检测采用酶联免疫吸附试验(ELISA)方法。结果:①白癜风患者血清抗酪氨酸酶IgG抗体平均滴度为0.316,显著高于正常对照组0.082(P<0.001);抗酪氨酸酶IgM抗体平均滴度为0.238,显著高于正常对照组0.065(P<0.001)。②活动期白癜风患者血清抗酪氨酸酶IgG、IgM抗体滴度明显高于稳定期白癜风患者(均P<0.001);泛发型白癜风患者血清抗酪氨酸酶IgG、IgM抗体滴度明显高于局限型白癜风患者(均P<0.001)。③抗酪氨酸酶IgG、IgM抗体滴度与抗黑素细胞IgG抗体阳性呈正相关(均P<0.001);抗酪氨酸酶IgG、IgM抗体滴度与抗黑素细胞IgM抗体阳性呈正相关(均P<0.001)。④糖皮质激素治疗后患者抗酪氨酸酶IgG、IgM抗体滴度均低于治疗前(均P<0.001)。结论:白癜风患者血清抗酪氨酸酶IgG、IgM抗体与疾病活动性和严重程度相关。
Objective： To investigate the relationship between the serum levels of anti - tyrosinase IgG and IgM antibodies and the disease activily of vililigo, and its signifieance. Methods： Anti - tyrusinase IgG and IgM antibodies were detected by enzyme linked immunoabsorbent assay. Results： The mean sera liter of anti - tyrosinase IgG antibody in the patients with vitiligo was 0.316 which was significantly higher than that of the heahhy controls （ P 〈 0.001 ） ; The mean tiler of anti - lyrosinase lgM anlihody in the sera of patients with vitiligo was 0.238 which was higher than that of the healthy controls （P〈 0.001）. The serum anti- tyrosinase IgG , IgM antitbodies tiler in the aetive vitiligo patients was significantly higher than that of stable vitiligo patients （ P 〈 0.001 ） ; The sera tilers of anti - tyrusinase IgG and IgM antibodies in the universal vitiligo patients was signifieantly higher than the levels in toealized vititigo patients （ P 〈 0.001 ）. The sera titers of anti - tyrosinase IgG and IgM antibodies were correlated positively with the degree of anti - lnelanocyte IgG antibody （ P 〈 0.001 ）. The sera titers of anti - tyrosinase IgG and lgM antibodies were correlated positivety with the degree of anti - melanocyte IgM antibody （ P 〈 0.001 ）, The sera tilers of anti - tyrusinase IgG, IgM antibodies were also higher before glucocorticoid treatment than those after treatment （ P 〈 0.001 ）. Conclusion： The levels of anti - tyrusinase IgG and IgM antibodies in the patients with vititigo have a strong correlation with activity and severity of the disease.
出处
《中国麻风皮肤病杂志》
2005年第9期682-684,共3页
China Journal of Leprosy and Skin Diseases
基金
2002年杭州市医药卫生科技资助项目(02B017)
