摘要
目的探讨血清白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)在白癜风患者发病中的作用。方法 36例白癜风患者为患者组,皮损分布局限型24例,其中进展期13例,稳定期11例;泛发型12例,其中进展期4例,稳定期8例。20例正常健康者为对照组,两组每人采静脉血3mL,采用双抗体夹心ELISA法检测TNF-α、IL-6含量。结果白癜风患者血清TNF-α水平高于正常对照组(P<0.05);其中局限型及泛发型白癜风患者血清TNF-α水平均高于正常对照组(P<0.05);局限型白癜风患者中进展期与稳定期患者TNF-α水平差异无统计学意义(P>0.05);泛发型白癜风患者中进展期与稳定期患者TNF-α水平差异有统计学意义(P<0.01)。白癜风患者血清IL-6水平高于正常对照组(P<0.05);其中局限型及泛发型白癜风患者血清IL-6水平均高于正常对照组(P<0.05及P<0.01);局限型白癜风患者中进展期与稳定期患者IL-6水平差异有统计学意义(P<0.05);泛发型白癜风患者中进展期与稳定期患者TNF-α水平差异有统计学意义(P<0.05)。结论 IL-6和TNF-α可能在白癜风发病中发挥一定作用。
Objective To investigate the serum levels of interleukin-6 (IL-6)and tumor necrosis fac-tor-alpha (TNF-α) in the pathogenesis of vitiligo patients. Methods Among 3 6 cases with vitiligo le-sions,limited distribution type was 24 cases,including 13 cases of advanced stage,11 cases of stable stage;12 cases were Pan hair type,including 4 cases of advanced stage,8 cases of stable stage.Mean-while 20 healthy cases were taken as controls.3 mL blood was taken from each case of two groups,and TNF-α,IL-6 were detected by double antibody sandwich ELISA method.Results Serum TNF-αlevel of Vitiligo patients was higher than that of normal control group (P<0.05);Wherein localized and general-ized vitiligo patients serum TNF-αlevels were higher than that of normal control group (P<0.05 );Difference of the TNF-αlevel had no statistical significance in patients with vitiligo confined in progress and stability (P>0.05);Difference in TNF-αwas statistically significant in patients with generalized viti-ligo in progress and stability (P<0.01).Serum IL-6 level in patients with vitiligo was higher than that of normal control group (P<0.05);The level of IL-6 in serum of patients with localized and generalized vit-iligo was higher than that of normal control group (P<0.05 and P<0.01),there were significant differ-ences;The difference of IL-6 between localized patients with vitiligo in progress and stability has statisti-cal significance (P<0.05);The difference in TNF-αlevels was statistically significant in patients with generalized vitiligo in progress and stability (P<0.05).Conclusion Serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)might play a role in the pathogenesis of vitiligo.
出处
《河北北方学院学报（自然科学版）》
2014年第1期71-73,共3页
Journal of Hebei North University:Natural Science Edition
基金
张家口市科学技术研究与发展指导计划项目(No.051162)
