摘要
为研究氟哌酸锌的制备，采用４种方法：氢氧化钠法、氨水法、碳酸氢钠法、碳酸钠法制备氟哌酸锌。实验表明碳酸钠法、碳酸氢钠法、氨水法均较氢氧化钠法为好。体外抑菌实验表明，氟哌酸锌对金葡球菌、大肠杆菌、绿脓杆菌的抑制作用明显高于磺胺嘧啶锌。
Zinc norfloxacin was prepared by four methods and evaluated for its antimicrobialactivities in vitro. The yield and content of the product by using methods of the sodium carbonate,sodium bicarbonate and ammonium hydroxide methods were higher than those by sodium hydrox-ide method. Zinc norfloxacin exhibited more potent antimicrobial activities against Escherichiacoli,Staphylococcus aureus and Pseudomonas aeruginosa than zinc sulfadiazine。
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第4期236-237,共2页
Chinese Pharmaceutical Journal
关键词
氟哌酸锌
制备
体外抑菌
zinc norfloxacin,preparation,antimicrobial activity
