摘要
目的研究瘦素(Leptin)和瘦素受体(ob-R)在胃癌组织中的表达并探讨其在胃癌发生、发展过程中的作用。方法采用免疫组织化学染色方法检测54例胃癌组织中瘦素和瘦素蛋白的表达,并就其表达与临床病理组织学参数之间的关系进行了相关性分析。结果54例胃癌组织中瘦素和瘦素受体的的表达率为72.22%(39/54)和74.07%(40/54),肠型胃癌瘦素表达率明显高于弥漫性胃癌。瘦素的表达率与肿瘤组织分化、癌肿大小、转移、TNM分期有关。结论瘦素和瘦素受体以双重表达方式存在于胃癌组织中,参与胃癌的早期发生过程并在其发展中起一定作用。
Objective To determine the expression of leptin and leptin receptor in gastric carcinoma and investigate their role in carciagenesis and development of gastric carcinoma.Methods The expression of leptin and leptin receptor protein was detected in 54 cases of gastric carcinoma tissues by immunohistochemistry.The correlatin between their expression and clinicallpathological parameters was also analysized.Results The expression rate of leptin and leptin receptor in gastric carcinoma was 72.22% (39/54) and 74.07% (40/54) respectively.The expression rate of leptin in intestinal-type gastric cancer was significantly higher than in diffuse-type gastric cancer.The expression rate of leptin was associated with differentiation,tumor size,metastasis,and TNM stage.Conlusion Leptin and leptin receptor were dually cxpressed in gastric carcinoma.They participate in the early stage of malignant transformation and have certain role in the advanced stage.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2005年第5期609-610,i004,共3页
Chinese Journal of Experimental Surgery
