摘要
芳酰基异硫氰酸酯与３，４，５－三甲氧基苯甲酰肼在无水乙腈中缩会，制得一系列新的１－（３，４，５－三甲氧基苯甲酰基）－４－芳酰基氨基硫脲。产物的结构已经元素分析、ＩＲ．１ＨＮＭＲ和ＭＳ方法确证。经初步筛选发现一些化合物有抑制大肠杆菌繁殖的活性。
A series of new 1-(3, 4, 5-trimethoxybenzoyl)4-aroylthiosemicarbazides 1(a-n) were synthesized by condensation of aroylisothiocyanates with 3, 4,5 trimethoxybenzoylhydrazine in absolute acetonitrile.Structures of compounds 1(a-n) and 2(a-n) were characterized by elemental analysis, IR, ￣1HNMR and MS.The inhibiting effects on B. Subtilis were also screened.
出处
《化学试剂》
CSCD
北大核心
1994年第4期211-214,共4页
Chemical Reagents
关键词
酰氨基硫脲
衍生物
合成
环化反应
trimethoxybenzoyl)-4-aroylthiosemicarbazides
2
5-disubstituted-1
3
4-thiadia zole
antibacterial actiyity
