摘要
应用高效波相色谱技术检测了大鼠肾囊注射丹参后不同时间肾脏组织和血液中丹参的浓度。结果显示肾脏组织中丹参浓度明显高于血中丹参浓度,24h达高峰,至48h仍维持在较高水平,且不依赖于血中丹参浓度变化。表明肾囊中丹参可被动转运至肾脏,形成肾脏高浓度区。以此可作为应用肾囊药物注射治疗多种肾脏疾病的基础。
The concentration of Salvia miltiorrhizae (SM) was detected at different time after renalintracapsular injection in S. D rats. It showed that SM concentration was higher in kidney than inplasma (P< 0.05). SM concentration in kidney increased gradually, it reached the peak at 24 hour andstill remained in higher level at 48 hour. The SM injected in renal capsule could be passivelytransported to renal tissue and maintained at a high level. This result demonstrated that renal intracapsular injection could be applied as an important therapeutical method for different renaldisease.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1993年第11期670-671,共2页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
肾囊注射
丹参
高效液相色谱
renal intracapsular injection
Salvia miltiorrhizae
