摘要
目的探讨胸痹通胶囊对大鼠急性缺血心肌的保护作用机制。方法将动物随机分为3组,即正常对照组(A组)、模型对照组(B 组)、模型治疗组(C)组,制作异丙基肾上腺素性心肌缺血模型,测定各组大鼠血浆中超氧化物歧化酶的总活性(T-SOD)、血栓素 A_2、前列腺素 PGI_2的中间代谢产物(TXB_2、6-Keto-PGF_(la))、血浆内皮素(ET)、血浆降钙素基因相关肽(CGRP)、心肌心钠素(ANF)及心肌 ATP 酶活性等的活性,并进行组间比较。结果心肌缺血(模型对照组)大鼠血浆 T-SOD 活性降低、TXB_2、ET 含量增加、6-Keto-PGF_(la)、CGRP 减少,心肌 ANF 减少,ATP 酶活性降低。而模型治疗组(胸痹通 XBTC 组)上述变化则明显改善。结论 XBTC 可通过提高 SOD、ATP 酶的活性以及纠正缺血时血管活性物质的释放而发挥心肌保护作用。
Objective To investigate the protective mechanism of XBTC in the rats with myocardial ischemia.Methods The myocardial is- chemia rat models were established with isopropylarterenol.Total activity of superoxide dismutase(T-SOD),the contents of TXB_2 and 6-Keto -PGF_(1a) (medial metabolism products of TXA_2 and PGI_2),The level of endothelin(ET),calcitionin gene related paptide(CGRP),cardiona- trin in plasma and the activity of ATPase in myocardial were measured.Results In the model control group,the activity T-SOD in the plasma lowered,the Plasma levels of TXB_2 and ET were increased.The contents of ANF,CGRP,and 6-Keto-PGF_(1a) decreased.The activity of ATPase in myocardial lowered,While in the model treat group(treated with XBTC),all these measures were obviously better than those in the control group respectively.Conclution XBTC has a significant protective effect on myocardial ischemia and the protective effect might associated with its effects of enhancing the activity of SOD and ATPase and rectifying the release of vasoactive substances.
出处
《医学研究通讯》
2005年第2期47-48,共2页
Bulletin of Medical Research
基金
潍坊市科委基金资助课题
