摘要
目的 探讨化疗加低剂量放疗综合治疗中晚期非小细胞肺癌的方法、疗效、预后及其副反应。方法 回顾性分析 6 8例经病理确诊为非小细胞肺癌患者资料 ,根据所接受的放疗剂量不同分成。治疗组 (化疗 +低剂量放疗 ) 33例和对照组 (化疗 +根治剂量放疗 ) 35例。两组均用CEP化疗方案 ,放疗剂量 ,其中治疗组 4 5Gy ,对照组 ( 6 0～ 70 )Gy。 结果 治疗组 1,2 ,3,4年生存率分别为 6 1% ,2 1.2 % ,9.1% ,9.1% ;对照组 1,2 ,3,4年生存率分别为 85 .7% ,11.4 % ,2 .86 % ,0 % ,两组生存率比较 ,1年生存率有显著性差异 (P <0 .0 5 ) ,2、3、4年生存率无显著性差异 (P >0 .0 5 ) ;骨髓抑制及放射性肺损伤两组比较差异存在显著性 (P <0 .0 5 )。结论 CEP方案化疗加低剂量放疗综合治疗中晚期NSCLC可明显减轻毒副作用。
Objective To evaluate the technique, effect, prognosis and side effects of chemotherapy combined with low dosage radiotherapy for patients with local and advanced non small cell lung cancer.Methods From July 1989 to July 2001, a total 68 patients with pathologically confirmed non small cell lung cancer were retrospectively analyzed. According to the different dosage radiotherapy, the patients were divided into treatment group(chemotherapy plus low dosage mdiotherapy) and control group(chemotherapy plus standard dosage radiotherapy). The chemotherapy regiment with CEP (CTX,DDP, VP 16) were used in two groups. The dosage of radiotherapy is 45Gy in treatment group and 60～70Gy in control group.Results The 1 ,2 ,3 and 4 year survival rates in treatment group and control group were 61%, 21.2% , 9.1% , 9.1% and 85.7% , 11.4% , 2.86% , 0% respectively. There was significant difference between two groups in 1 year survival rate. There was not significant difference between two groups in 2 ,3 ,4 year survival rates. There was significant difference between two groups in hemotologic toxicities and radio lung injury.Conclusion Chemotherapy combined with low dosage radiotherapy for patients with local and advanced non small cell lung cancer could significantly improve quality of life with achieving equal the survival between two groups.
出处
《肿瘤防治研究》
CAS
CSCD
2004年第8期492-494,共3页
Cancer Research on Prevention and Treatment
关键词
肺小细胞肺癌
综合治疗
放疗
化疗
Non-small cell lung cancer
Combined modality therapy
Radiotherapy
Chemotherapy
