摘要
对８０例以Ⅲ期为主的晚期肺癌，采用前瞻性任意选择法，比较二组治疗方案的优劣。用生命表Ｋａｐｌａｎｍｅｉｒ计算生存率，并用时序检验、ＣＯＸ多因素分析和单位时间点作统计学检验。４０例小细胞肺癌中，化疗－手术－化疗组和化疗－放疗－化疗组各２０例。前者１～３年生存率优于后者，单位时间点统计２年生存率差异有显著性意义（Ｐ＜０．０５）。因此，应争取化疗缓解后手术。另４０例非小细胞肺癌，大都为Ⅲ、Ⅲ晚期，前瞻性任意选择法分组，化疗－放疗－化疗组和放疗－化疗组各２０例ＣＯＸ多因素分析表明二组的１、２年生存率分别为６６．７％、４０％和２１．８％、１５．２％。差异有显著性意义。
AbstractA prospective randomized study of 80 cases of stage Ⅲ
lung cancer treated with differentmultimodality therapy was carried
out.Life table and Kaplan-Meir curve were employed to calcu-late
survival rate. Log rank-multivariate analysis and time t test were
used to evaluate statisticalvalues of the 80 cases,40 SCLC were
randomly treated with either chemotherapy(CT)-surgery-CT or
CT-radiatherapy(RT)-CT. The year survival rates were better in the
group treated withCT-surgery-CT,a statistical difference was observed
in 2yr survival rate(P<0.05).Thus,sur-gical resection for SCLC was
better than RT after CT,The remaining 40 cases of NSCLC wererendomly
treated with either CT-R-CT or RT-CT. Multivariate analvsis showed a
better statis-tical meaning in the 20 cases treated with CT-RT-CT
than the other group,their 1,2 year sur-vival rates were 27%,40%and
22%, 15%,respectively. Thus preradiative CT was beneficialfor
survival.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1995年第5期384-386,共3页
Chinese Journal of Oncology
