摘要
目的:观察良、恶性单克隆Ig增殖病血清及尿液中κ、λ轻链水平和κ/λ比率变动的意义。方法:以散射浊度法检测162例各类单克降Ig增殖病患者血清及部分尿液三种Ig、κ、λ轻链含量,计算出κ/λ比率。结果:109例健康κ/λ比率为(1.70±0.41)。152例MMG正常Ig水平均显著减低,κ型κ/λ比率为(5.3～493);λ型κ/λ比率为0.006～0.23。10例BMG及32例多克隆高丙种球蛋白血症κ/λ比率接近正常人。17例BIP型中仅4例血清轻链明显升高且出现M带,而17例尿中均出现单一的轻链型M带。结论:血清及尿液κ、λ定量和κ/λ比率对BMG与MMG、轻链病、单克隆与多克隆Ig增殖病的诊断与鉴别诊断有确诊意义。
Objective To explore the diagnostic value of changes in the κ and λ Light chains of serum and urine to monoclonal gammopathy (MG). Methods Three sorts of Ig,and κ and λ light chairs were detected by the nephelometry in 162 patients with MG, 32 with polyclonal hypergammaglobuliemias(PHG)and 109 healthy subjects. The ratio of the κ to λ was calculated. Results The ratio of the κ to λ was 1.70±0.41 in 109 heathy subjects. The serum Ig levels were Significantly lower in 155 patients with malignant MG (MMG) than that in 109 healthy subjects. The ratio of the κ to λ was from 5.3 to 493 in the patients with κ type of MMG, from 0.006 to 0.23 in the patients with λ type of MMG.The ratio of the κ to λ in 32 patients with PHG and 10 with benign MG (BMG) approximated to that in 109 healthy subjects. The increase in the serum light chain where M band appeared, was observed in only 4 of 17 patients with BJP, but in the urine sole light chain M band appeared in all the patients with BJP. Conclusion The changes in the κ and λ light chains ,and their ratio in the serum and urine are of deerminant value to diagnosis and differertiation of the BMG, MMG and PHG.
出处
《华南国防医学杂志》
CAS
2003年第6期6-8,共3页
Military Medical Journal of South China
