摘要
以α-生育酚作为对照,研究茶多酚、没食子酸、槲皮素、山奈素、芹菜素五种多酚化合物对H2O2和CCl4诱导的人肝细胞损伤的保护作用。结果表明,不同浓度的多酚化合物(5、10、20mg/L)与肝细胞预先作用1h,再进行诱导损伤,可以提高肝细胞的细胞活率和还原型谷胱甘肽(GSH)含量水平,降低乳酸脱氢酶(LDH)渗出率和丙二醛(MDA)生成量。显示它们对H2O2和CCl4诱导的肝细胞损伤有保护作用,保护能力大小顺序为没食子酸>槲皮素>茶多酚>芹菜素>α-生育酚>山奈素。其保护作用可能与多酚化合物具有较强的清除自由基能力有关。
The potential hepatoprotective effects of five polyphenols,such as tea polyphenol,gallic acid,quercetin,kaempferol,apigenin and α-tocopherol(as a control) against oxidation damages of human hepatocyte induced by hydrogen peroxide or carbon tetrachloride were evaluated.The results showed that pre-treatment of hepatocytes with polyphenols at concentrations of 5,10 and 20 mg/L for 1 h not only improve cell viability and the content of GSH,but also reduce LDH leakage and the formation of MDA in cells.The hepato...
出处
《食品科学》
CAS
CSCD
北大核心
2009年第3期262-266,共5页
Food Science
关键词
多酚化合物
肝细胞
诱导损伤
过氧化氢
四氯化碳
polyphenol compounds
hepatocyte
induced damage
hydrogen peroxide
carbon tetrachloride
