摘要
目的探讨针刺、丁苯酞胶囊联合计算机辅助认知康复训练治疗脑卒中后认知功能障碍的效果。方法将78例该院收治的脑卒中认知功能障碍患者随机分为对照组和观察组各39例。对照组患者给予丁苯酞胶囊联合计算机辅助认知康复训练治疗,观察组在对照组基础上加以针刺治疗,对比两组的临床治疗效果、认知功能评分、神经功能评分及神经行为认知状况测试(NCSE)评分,测定大脑中动脉血流速度,监测血清中神经营养状态指标、神经损伤标志物水平。结果观察组、对照组的有效率分别为92.31%(36/39)、74.36%(29/39),以观察组临床效果更好(χ2=4.523,P<0.05);观察组患者经治疗后的认知功能、神经功能改善均优于对照组,注意力、记忆力、定向力、执行力、思维推理力改善更明显,与对照组相比,其MoCA评分、NCSE评分显著升高,NIHSS评分显著降低(P<0.05);观察组患者的脑血流Vs、Vm、Vd水平更高,脑血液灌注状态改善更明显(P<0.05);观察组患者血清中BDNF含量显著升高,VILIP-1、NSE含量则显著降低(P<0.05)。结论针刺、丁苯酞胶囊联合计算机辅助认知康复训练利于促进脑卒中后认知功能障碍的恢复,促进脑血流量的恢复,上调血清中BDNF含量,抑制VILIP-1、NSE表达,修复受损的神经功能,值得进行临床推广。
Objective To investigate the effect of acupuncture and Butylphthalide Capsule combined with computer aided cognitive rehabilitation training on the treatment of cognitive dysfunction after stroke.Methods A total of 78 stroke patients with cognitive dysfunction in our hospital were randomly divided into control group and observation group,39 cases in each.Patients in the control group were treated with Butylphthalide Capsules combined with computer aided cognitive rehabilitation training,and patients in the observation group were treated with acupuncture on the basis of the control group.Clinical treatment effect,cognitive function score,neurological function score and neurobehavioral cognitive status examination(NCSE)score of the two groups were compared,blood flow velocity of middle cerebral artery was measured,and the level of neurotrophic status index and neurological injury markers in serum was monitored.Results The effective rate of observation group and control group was 92.31%(36/39)and 74.36%(29/39)respectively.The clinical effect was better in the observation group(χ~2=4.523,P<0.05).The improvement of cognitive function and neurological function in the observation group after treatment was better than that in the control group,and the improvement of attention,memory,orientation,executive ability and thinking and reasoning ability was more obvious.Compared with those of the control group,the MoCA score and NCSE score were significantly increased,while the NIHSS score was significantly decreased(P<0.05).In the observation group,the levels of cerebral blood flow Vs,Vm and Vd were higher,and the improvement of cerebral blood perfusion was more obvious(P<0.05).In the observation group,BDNF content in serum significantly increased,while contents of VILIP-1 and NSEsignificantly decreased(P<0.05).Conclusion Acupuncture and Butylphthalide Capsules combined with computer aided cognitive rehabilitation training can promote the recovery of cognitive dysfunction after stroke,promote the recovery of cerebral blood fl
作者
李朝健
陈文远
王小桥
LI Chaojian;CHEN Wenyuan;WANG Xiaoqiao(Rehabilitation Medicine of Hainan people's Hospital,Hainan Hospital Affiliated to Hainan Medical College,Haikou 570206,Hainan,China)
出处
《辽宁中医杂志》
CAS
2020年第8期158-161,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
脑卒中后认知功能障碍
针刺
丁苯酞胶囊
计算机辅助认知康复训练
cognitive dysfunction after stroke
acupuncture
Butylphthalide Capsule
computer aided cognitive rehabilitation training
