摘要
目的:研究经颅直流电刺激(tDCS)联合计算机辅助认知康复训练改善帕金森病(PD)患者认知功能障碍的临床疗效。方法:将我院帕金森合并认知障碍患者22例随机分为对照组和tDCS组各11例。2组患者均延续正规抗帕金森药物治疗方案,同时加以计算机辅助认知康复训练,tDCS组在此基础上增加tDCS治疗,对照组予以假性刺激。治疗前及治疗4周后,采用简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)、洛文斯顿认知功能评定测验(LOTCA)和D2注意力测验量表对2组患者进行评定。结果:治疗4周后,2组MMSE、MoCA、LOTCA的6个方面及D2注意力测验量表评分较治疗前均明显提高(均P<0.05),且tDCS组以上评分较对照组均明显提高(均P<0.05)。结论:经颅直流电刺激联合计算机辅助认知康复训练可改善帕金森病患者认知功能。
Objective:To investigate the efficacy of transcranial direct current stimulation(tDCS)combined with cognitive training in the improvement of cognitive impairment in Parkinson disease(PD).Methods:Twenty-two patients with Parkinson disease combined with cognitive impairment in our hospital were randomly divided into a control group and tDCS group,n=11 each.The patients in both groups were given the regular anti-Parkinson drug treatment program,and at the same time received computer-aided cognitive rehabilitation training.The tDCS group was treated by tDCS treatment additionally,and the control group was subjected to false stimulation.Before and 4 weeks after treatment,the patients were assessed by the Mini Mental State Scale(MMSE),Montreal Cognitive Assessment Scale(MoCA),Lowenston Cognitive Function Assessment Test(LOTCA)and D2 Attention Scale.Results:After 4 weeks of treatment,the scores of the MMSE,MoCA,LOTCA and D2 attention test scales in the two groups were significantly higher than those before treatment(all P<0.05),and the scores above after treatment in the tDCS group were significantly higher than those in the control group(all P<0.05).Conclusion:The tDCS combined with cognitive training can significantly improve cognitive impairment of patients with PD.
作者
孙莉
王舒
叶维
莫丹
Sun Li;Wang Shu;Ye Wei(General Hospital of the Yangtze River Shipping, Wuhan 430010, China)
出处
《中国康复》
2020年第6期308-311,共4页
Chinese Journal of Rehabilitation
基金
武汉市卫生健康科研基金资助(WX19D58)。
关键词
帕金森病
经颅直流电刺激
认知障碍
注意力
Parkinson disease
transcranial direct current stimulation
cognition disorders
attention
