摘要
目的:分析自拟活血化瘀醒脑汤治疗脑卒中后认知功能障碍的作用机制。方法:86例脑卒中后认知功能障碍患者按照随机数表法将患者分为对照组和观察组,每组各43例。对照组患者给予常规治疗,观察组在对照组治疗基础上给予自拟活血化瘀醒脑汤。两组患者疗程均为4周。治疗结束后,比较两组患者临床疗效,分别于治疗前后采用简易智力状况检查法(mini-mental state examination,MMSE)评价两组患者的智力情况,比较患者血液流变学、脑血流动力学及血清炎症指标水平变化情况。结果:观察组有效率为81. 39%(35/43),明显高于对照组的51. 16%(22/43),差异有统计学意义(P <0. 05)。与治疗前比较,两组患者治疗后MMSE评分、动脉血流平均流速、大脑前动脉流速和大脑中动脉流速水平均明显升高,而血液流变学指标、血管阻力指数、搏动指数及血清炎症指标均显著降低,差异均有统计学意义(P <0. 05);观察组以上指标改善情况显著优于对照组,差异均有统计学意义(P <0. 05)。结论:自拟活血化瘀醒脑汤治疗脑卒中后认知功能障碍临床疗效显著,可改善血液流变学、脑血流动力学及血清炎症指标,改善脑卒中后认知功能障碍。
Objective: To analyze the mechanism of self-made Huoxue Huayu Xingnao Decoction in the treatment of stroke cognitive dysfunction. Methods: 86 patients with post-stroke cognitive dysfunction were divided into control group and observation group according to the random number table method,with 43 cases in each group. The patients in the control group were given conventional treatment,and the observation group was given the self-made Huoxue Huayu Xingnao Decoction on the basis of the treatment of the control group. The course of treatment for both groups was 4 weeks. After the end of treatment,the clinical efficacy of the two groups of patients were compared. The intelligence of the two groups was evaluated by mini-mental state examination( MMSE) before and after treatment. The blood rheology and cerebral hemodynamics and changes in serum inflammatory markers were compared. Results: The effective rate of the observation group was 81. 39%( 35/43),which was significantly higher than 51. 16% of the control group( 22/43). The difference was statistically significant( P < 0. 05). Compared with before treatment,the MMSE score,mean flow rate of arterial blood flow,anterior cerebral artery velocity,and middle cerebral artery flow rate were significantly increased after treatment. The hemorheology index,vascular resistance index,pulsation index and serum inflammation index were significantly decreased,and the differences were statistically significant( P < 0. 05). The improvement of the above indicators in the observation group was significantly better than that of the control group,and the difference was statistically significant( P <0. 05). Conclusion: Self-made Huoxue Huayu Xingnao Decoction is effective in the treatment of stroke cognitive dysfunction,which can improve hemorheology,cerebral hemodynamics and serum inflammation,and improve cognitive dysfunction in stroke.
作者
魏东宝
高颖
游玉红
蔡凯
陈志恒
那黎明
杨丽琴
WEI Dongbao;GAO Ying;YOU Yuhong;CAI Kai;CHEN Zhiheng;NA liming;YANG Liqin(Xuchang Central Hospital,Xuchang Henan China 461000;Chinese Medicine Hospital of Chongqing City,Chongqing China 400021)
出处
《中医学报》
CAS
2019年第1期131-135,共5页
Acta Chinese Medicine
基金
国家自然科学基金项目(30870844)
关键词
活血化瘀醒脑汤
脑卒中
认知功能障碍
血液流变学
脑血流动力学
炎症指标
MMSE评分
中西医结合
Huoxue Huayu Xingnao Decoction
stroke
cognitive dysfunction
hemorheology
cerebral hemodynamics
inflammatory index
MMSE score
integration of traditional and western medicine
