摘要
【目的】探讨大黄凉血汤在晚期肺癌咯血患者中的临床治疗效果及对凝血因子的影响。【方法】将80例晚期肺癌咯血患者随机分为研究组和对照组,每组各40例。对照组患者采用含铂方案治疗,研究组在对照组的基础上应用大黄凉血汤治疗,连续治疗4个月。观察2组患者治疗前后炎性因子[降钙素原(PCT)和C反应蛋白(CRP)]水平、不良反应发生率、肿瘤标志物[癌胚抗原(CEA)、骨胶素(CY211)、糖类抗原125(CA125)]水平以及凝血因子[血小板计数(PLT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]水平的变化情况。【结果】(1)炎性因子水平方面,治疗后,2组患者的PCT、CRP水平均较治疗前明显降低(P<0.05),且研究组的降低作用均明显优于对照组(P<0.05)。(2)肿瘤标志物水平方面,治疗后,2组患者的CEA、CY211、CA125水平均较治疗前明显降低(P<0.05),且研究组的降低作用均明显优于对照组(P<0.05)。(3)凝血因子水平方面,治疗后,2组患者的PLT水平均较治疗前明显升高(P<0.05),PT、APTT水平均较治疗前明显降低(P<0.05),且研究组对PLT水平的升高作用及对PT、APTT水平的降低作用均明显优于对照组(P<0.05)。(4)药物毒副作用发生情况方面,研究组患者的白细胞减少、中性粒细胞减少、血小板减少、胃肠道反应、肝肾功能异常和骨髓抑制等药物毒副作用发生情况均明显少于对照组,差异均有统计学意义(P<0.05)。【结论】大黄凉血汤可有效提高含铂方案治疗晚期肺癌咯血患者的临床疗效,有利于控制病情,减少用药毒副作用,改善肿瘤标志物、炎性因子以及凝血因子水平。
Objective To investigate the therapeutic effect of Dahuang Liangxue Decoction in treating hemoptysis patients with advanced lung cancer,and to observe its influence on coagulation factors.Methods Eighty hemoptysis patients with advanced lung cancer were randomly divided into study group and control group,with 40 cases in each group.The control group was treated with platinum-containing chemotherapy,and the study group was treated with Dahuang Liangxue Decoction on the basis of treatment for the control group for 4 consecutive months.The changes in the levels of inflammatory factors of procalcitonin(PCT)and C-reactive protein(CRP),the incidence of adverse reaction,the levels of tumor markers of carcinoembryonic antigen(CEA),osteopontin(CY211),carbohydrate antigen 125(CA125),and the coagulation factors of platelet(PLT)count,activated partial thromboplastin time(APTT),and prothrombin time(PT)in the two groups were observed before and after treatment.Results(1)Inflammatory factors:after treatment,the levels of PCT and CRP in the two groups were significantly decreased compared with those before treatment(P<0.05),and the effect on lowering PCT and CRP levels in the study group was significantly superior to that in the control group(P<0.05).(2)Tumor marker levels:after treatment,CEA,CY211 and CA125 levels in the two groups were significantly decreased compared with those before treatment(P<0.05),and the effect on lowering the CEA,CY211 and CA125 levels in the study group was significantly superior to that in the control group(P<0.05).(3)Coagulation factor levels:after treatment,PLT count in the two groups was significantly increased and PT and APTT levels were significantly decreased compared with those before treatment(P<0.05),and the effect on increasing PLT count and on decreasing the PT and APTT levels in the study group was significantly superior to that in the control group(P<0.05).(4)The occurrence of drug toxic and side effects:the incidence of leucopenia,neutropenia,thrombocytopenia,gastrointestinal reaction,a
作者
许斌
李文婷
陶承志
王羽超
XU Bin;LI Wen-Ting;TAO Cheng-Zhi;WANG Yu-Chao(Nanjing Chest Hospital,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029 Jiangsu,China;The First Clinical Medical School of Nanjing University of Chinese Medicine,Jiangsu Collaborative Innovation Center for Cancer Prevention and Treatment with Traditional Chinese Medicine,Nanjing 210029 Jiangsu,China)
出处
《广州中医药大学学报》
CAS
2022年第5期1007-1012,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:81804058)
关键词
大黄凉血汤
晚期肺癌
咯血
凝血因子
炎性因子
肿瘤标志物
Dahuang Liangxue Decoction
advanced lung cancer
hemoptysis
coagulation factors
inflammatory factors
tumor markers
