摘要
目的探讨靶向治疗联合放化疗在肺癌脑转移患者治疗中的应用效果。方法将90例肺癌脑转移患者分为对照组和研究组两组,每组45例,对照组患者接受放化疗治疗,研究组患者在对照组的基础上联合靶向治疗,比较两组患者的近期疗效、不良反应、生存时间及生活质量。结果研究组患者ORR为71.11%,对照组患者ORR为42.22%,两组比较存在统计学差异(P<0.05),研究组患者骨髓抑制、胃肠道反应及皮疹脱屑的发生率显著低于对照组(P<0.05),两组肝功能损伤及血液不良反应的发生率比较无统计学差异(P>0.05),研究组患者治疗后半年、1年、2年及中位生存期均显著高于对照组(P<0.05),研究组患者的生活质量改善情况显著优于对照组(P<0.05)。结论靶向治疗联合放化疗可有效提高近期疗效及患者的生活质量,延长生存期,且可减少骨髓抑制、胃肠道反应及皮疹脱屑等不良反应,在肺癌脑转移患者治疗中具有较高的应用价值。
Objective To explore application effect of targeted therapy combined with radiotherapy and chemotherapy in the treatment for lung cancer patients with brain metastases.Methods 90 patirnts for lung cancer with brain metastases were selected as research object and conducted retrospective study,According to the order of treatment,the subjects were divided into the control group and the study group,and each group of 45 cases.The control group received radiotherapy and chemotherapy treatment,the study group on the basis of the control group received targeted therapy.The short-term efficacy,adverse reactions,survival time and quality of life were compared the 2 groups.Results The ORR of the study group was 71.11%,and the ORR of the control group was 42.22%.There was significant difference between the 2 groups(P<0.05).The incidence of bone marrow suppression,gastrointestinal reactions and rash desquamation in the study group was significantly lower than that of the control group(P<0.05).There was no significant difference in the incidence of liver function damage and blood adverse reactions between the 2 groups(P>0.05).The half-year,1-year,2-year and median survival of the study group were significantly higher than those of the control group(P<0.05).The quality of life improvement of the study group was significantly better than that of the control group(P<0.05).Conclusion Targeted therapy combined with radiotherapy and chemotherapy could effectively improved the short-term efficacy and quality of life,prolong survival,and could reduce adverse reactions such as bone marrow suppression,gastrointestinal reactions and rash desquamation,which has high application value in the treatment of lung cancer with brain metastases.
作者
黄晓
张军营
王少芳
HUANG Xiao;ZHANG Junying;WANG Shaofang(Anyang People's Hospital,Anyang,455000)
出处
《实用癌症杂志》
2020年第6期967-970,共4页
The Practical Journal of Cancer
关键词
靶向治疗
放化疗
肺癌
脑转移
生存质量
不良反应
Targeted therapy
Radiotherapy and chemotherapy
Lung cancer
Brain metastasis
Quality of life
Toxic side reaction
