摘要
中药多组分复杂性药理作用量效关系是难以把握的“不传之秘”,经典的剂量-效应模型在方药量效关系研究中受到严峻挑战。近年一种新的毒物兴奋效应模型(Hormesis效应)用于非典型剂量-反应关系受到关注。我们基于模式生物费氏弧菌建立Hormesis效应测试关键技术平台,实现对中药Hormesis效应的精准识别和客观评价,可客观描述复杂性中药的非典型剂量-反应关系,科学阐释中药通过Hormesis剂量反应机制发挥双相调节作用科学假说,为建立精准的中药治疗剂量和临床合理用药方案提供新的科学依据。
The dose-response relationship in the complex pharmacological actions of multiple components of Chinese medicine is a"secret"that is difficult to grasp.The classical dose-response model is severely challenged in the study of dose-response relationship of Chinese medicinal prescriptions.In recent years,a new model of toxic and excitatory effect(hormesis effect)has attracted much attention for the application of atypical dose-response relationship.Based on the model organism Vibrio fischeri,we have established a key technology platform for the hormesis effect to achieve accurate identification and objective evaluation of the hormesis effect in Chinese medicine.It can objectively describe the atypical dose-response relationship of complex Chinese medicine,scientifically explain the scientific hypothesis that Chinese medicine plays a biphasic regulatory role through hormesis dose-response mechanism,and provide a new scientific basis for determining the accurate therapeutic dosage of Chinese medicine and development a clinical protocol for rational medication.
作者
鄢良春
华桦
田韦韦
赵军宁
戴瑛
李莉
曾瑾
尹竹君
曾安琪
张翼冠
王剑波
谭鹏
谭蕊蓉
Yan Liangchun;Hua Hua;Tian Weiwei;Zhao Junning;Dai Ying;Li Li;Zeng Jin;Yin Zhujun;Zeng Anqi;Zhang Yiguan;Wang Jianbo;Tan Peng;Tan Ruirong(Sichuan Academy of Chinese Medical Sciences,Sichuan Institute for Translational Chinese Medicine,State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,Sichuan Key Laboratory of Translational Chinese Medicine,Sichuan Engineering Technology Research Center for Formation Principle and Quality Evaluation of Genuine Medicinal Materials,Sichuan Engineering Technology Research Center for System Development of Genuine Medicinal Materials,Laboratory for Rapid Detection of Toxicity of Traditional Chinese Medicine in Sichuan Provincial Administration of Chinese Medicine,Chengdu 610041)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2022年第3期2-8,共7页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家重点基础研究发展计划(973计划)课题(编号:2009CB522801)
国家重大新药创制专项课题(编号:2015ZX09501004-001-005、2011ZX09401-304)
国家自然基金面上项目(编号:81073047、81470180)
四川省杰出青年基金团队项目(编号:2017TD0003)
四川省杰出青年科技人才项目(编号:2020JDJQ0063)
四川省科技计划重点研发项目(编号:2020YFS0566)
四川省中医药管理局科研专项(编号:2021ZD001)
四川省重大科技专项课题(编号:2018SZDZX0004)
广东省新黄埔中医药联合创新研究院联合创新研究项目(编号:2021IR002、2022IR014)
关键词
中药
适度调节原理
费氏弧菌
Hormesis效应
非典型剂量-反应关系
Chinese medicine
Moderation-integrated-balance presupposition
Vibrio fischeri
Hormesis effect
Atypical dose-response relationship
