The research and development （R＆D） process of Chinese medicine, with one notable feature, clinical application based, is significantly different from which of chemical and biological medicine, from laboratory resea...The research and development （R＆D） process of Chinese medicine, with one notable feature, clinical application based, is significantly different from which of chemical and biological medicine, from laboratory research to clinics. Besides, compound prescription is another character. Therefore, according to different R＆D theories between Chinese and Western medicine, we put forward a new strategy in drug design of Chinese medicine, which focuses on ＂combination- activity relationship （CAR）＂, taking prescription discovery, component identification and formula optimization as three key points to identify the drugs of high efficacy and low toxicity. The method of drug design of Chinese medicine includes： new prescription discovery based on clinical data and literature information, component identification based on computing and experimental research, as well as formula optimization based on system modeling. This paper puts forward the concept,research framework and techniques of drug design of Chinese medicine, which embodies the R＆D model of Chinese medicine, hoping to support the drug design of Chinese medicine theoretically and technologically.展开更多
文摘The research and development （R＆D） process of Chinese medicine, with one notable feature, clinical application based, is significantly different from which of chemical and biological medicine, from laboratory research to clinics. Besides, compound prescription is another character. Therefore, according to different R＆D theories between Chinese and Western medicine, we put forward a new strategy in drug design of Chinese medicine, which focuses on ＂combination- activity relationship （CAR）＂, taking prescription discovery, component identification and formula optimization as three key points to identify the drugs of high efficacy and low toxicity. The method of drug design of Chinese medicine includes： new prescription discovery based on clinical data and literature information, component identification based on computing and experimental research, as well as formula optimization based on system modeling. This paper puts forward the concept,research framework and techniques of drug design of Chinese medicine, which embodies the R＆D model of Chinese medicine, hoping to support the drug design of Chinese medicine theoretically and technologically.
基金Supported by 863 Program of Chinese Science & Technology Ministry(2004AA2Z4120)and.by Scientific Research Foundation for Doctoral Discipline of Chinese Ministry(20040712018)
文摘结合中国现实国情,应用先进的单片机、G IS、GPS以及变量控制技术,设计了一种经济实用、先进的变量灌溉控制系统。系统设计采用AT 89C 51单片机作为系统微处理器,Jup iter GPS OEM二次开发作为GPS接收机,IC卡作为G IS数据传递媒体,并根据矢量法提出一种简单快速的田间定位和数据查询算法。灌溉机在田间工作时,系统可从GPS OEM得到位置信息,进行地块识别和位置判断;然后根据位置信息从IC卡的G IS信息中查询土壤属性数据或处方数据,结合机械行走速度、施水幅宽等进行运算,得出某一时刻的灌水量;最后向控制器发出指令,实现变量节水灌溉。田间和实验室模拟试验结果表明,自行研制的低成本GPS OEM接收机,可获得与A g GPS132相当的定位精度,控制系统能根据处方图的不同需水量,通过电磁阀驱动电路得到变化的输出,实现自动变量施水,系统也能根据需水量进行手动灌溉。
