目的探究牙痛宁酊辅助根管植入对牙周炎患者血清白细胞介素-8（interleukin 8,IL-8）、白细胞分化抗原4（cluster of differentiation 4,CD4）及热休克蛋白70（heat shock protein 70,HSP70）水平影响。方法收集2013年12月~2015年9月浙...目的探究牙痛宁酊辅助根管植入对牙周炎患者血清白细胞介素-8（interleukin 8,IL-8）、白细胞分化抗原4（cluster of differentiation 4,CD4）及热休克蛋白70（heat shock protein 70,HSP70）水平影响。方法收集2013年12月~2015年9月浙江省余姚市第二人民医院口腔科收治的牙周炎患者64例,根据治疗方法不同分为对照组和治疗组,治疗组33例,对照组31例,2组患者均实施根管植入治疗,治疗组在此基础上实施速效牙痛宁酊治疗方案,治疗结束后对比分析2组患者临床疗效、疼痛发生率、IL-8、CD4及HSP70水平。结果治疗组临床总有效率为96.97%（32例）,显著高于对照组的80.65%（31例）（χ2=4.373,P〈0.05）。治疗组疼痛发生率为30.30%（10例）,显著低于对照组的58.06%（18例）（χ2=5.006,P〈0.05）。治疗后,2组血清IL-8水平均明显升高,CD4、HSP70水平显著降低（P〈0.05）,与对照组相比,治疗组血清IL-8水平显著升高,CD4、HSP70水平显著降低（P〈0.05）。结论牙痛宁酊辅助根管植入提高根管治疗效果,缓解牙组织损伤,改善手术后患者疼痛。展开更多
Overexpression of receptor-interacting protein 140（RIP140） promotes neuronal differentiation of N2 a cells via extracellular regulated kinase 1/2（ERK1/2） signaling.However,involvement of RIP140 in human neural dif...Overexpression of receptor-interacting protein 140（RIP140） promotes neuronal differentiation of N2 a cells via extracellular regulated kinase 1/2（ERK1/2） signaling.However,involvement of RIP140 in human neural differentiation remains unclear.We found both RIP140 and ERK1/2 expression increased during neural differentiation of H1 human embryonic stem cells.Moreover,RIP140 negatively correlated with stem cell markers Oct4 and Sox2 during early stages of neural differentiation,and positively correlated with the neural stem cell marker Nestin during later stages.Thus,ERK1/2 signaling may provide the molecular mechanism by which RIP140 takes part in neural differentiation to eventually affect the number of neurons produced.展开更多
文摘目的探究牙痛宁酊辅助根管植入对牙周炎患者血清白细胞介素-8（interleukin 8,IL-8）、白细胞分化抗原4（cluster of differentiation 4,CD4）及热休克蛋白70（heat shock protein 70,HSP70）水平影响。方法收集2013年12月~2015年9月浙江省余姚市第二人民医院口腔科收治的牙周炎患者64例,根据治疗方法不同分为对照组和治疗组,治疗组33例,对照组31例,2组患者均实施根管植入治疗,治疗组在此基础上实施速效牙痛宁酊治疗方案,治疗结束后对比分析2组患者临床疗效、疼痛发生率、IL-8、CD4及HSP70水平。结果治疗组临床总有效率为96.97%（32例）,显著高于对照组的80.65%（31例）（χ2=4.373,P〈0.05）。治疗组疼痛发生率为30.30%（10例）,显著低于对照组的58.06%（18例）（χ2=5.006,P〈0.05）。治疗后,2组血清IL-8水平均明显升高,CD4、HSP70水平显著降低（P〈0.05）,与对照组相比,治疗组血清IL-8水平显著升高,CD4、HSP70水平显著降低（P〈0.05）。结论牙痛宁酊辅助根管植入提高根管治疗效果,缓解牙组织损伤,改善手术后患者疼痛。
基金supported by the National Natural Science Foundation of China,No.31340024
文摘Overexpression of receptor-interacting protein 140（RIP140） promotes neuronal differentiation of N2 a cells via extracellular regulated kinase 1/2（ERK1/2） signaling.However,involvement of RIP140 in human neural differentiation remains unclear.We found both RIP140 and ERK1/2 expression increased during neural differentiation of H1 human embryonic stem cells.Moreover,RIP140 negatively correlated with stem cell markers Oct4 and Sox2 during early stages of neural differentiation,and positively correlated with the neural stem cell marker Nestin during later stages.Thus,ERK1/2 signaling may provide the molecular mechanism by which RIP140 takes part in neural differentiation to eventually affect the number of neurons produced.
