Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive n...Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive neuroscience and clinical studies. A number of comprehensive software packages have been developed for RS-fMRI data analysis, among which a MATLAB package named REST (RESing-state fMRI data analysis Toolkit, released in October 2008 at http://www.restfmri.net)[3] is the earliest one dedicated to RS-fMRI analysis. REST focuses on RS-fMRI postprocessing metrics.展开更多
目的利用静息态功能磁共振成像(rs-fMRI)技术,选取动态低频振荡振幅(dynamic amplitude of lowfrequency fluctuation,dALFF)方法,动态探测不同训练程度的乒乓球运动员脑功能活动的可塑性变化,以更精确地分析乒乓球项目特征,并为乒乓球...目的利用静息态功能磁共振成像(rs-fMRI)技术,选取动态低频振荡振幅(dynamic amplitude of lowfrequency fluctuation,dALFF)方法,动态探测不同训练程度的乒乓球运动员脑功能活动的可塑性变化,以更精确地分析乒乓球项目特征,并为乒乓球运动员的训练监控与评价提供科学依据。方法招募乒乓球专业队运动员、专业体育院校乒乓球专项学生以及性别、年龄与之匹配的普通被试,分别进行乒乓球训练情况调查。采集3组被试rs-fMRI相关数据,计算大脑dALFF指标并进行方差分析,提取差异脑区的dALFF值做双样本t检验并做Bonferroni校正;同时分别将组间差异脑区dALFF值与运动员周训练时长进行Pearson相关分析。结果 3组被试左侧小脑及左侧颞中回的dALFF值均有显著差异[体素P<0.01,团块P<0.05,高斯随机场(GRF)校正,体素>40]。事后检验发现,大学生运动员/专业运动员左侧小脑dALFF值均显著高于普通被试(P<0.05),大学生运动员左侧颞中回dALFF值显著高于其他2组被试(P<0.05),且均呈现大学生运动员>专业运动员>普通被试的变化趋势。专业运动员左侧小脑及左侧颞中回dALFF值与周训练时长均不存在相关性(P>0.05),而大学生运动员左侧小脑及左侧颞中回dALFF值与周训练时长呈显著负相关(r值分别为–0.4382和–0.4115,均P<0.05)。结论乒乓球运动可以引起大脑可塑性变化。乒乓球运动员在不同训练程度下可发生大脑(快速)运动平衡和视觉运动协调相关脑区的功能变化,其局部脑区脑自发活动的变异性在运动训练前期强于后期,且随着训练时长的增加,脑自发活动趋于稳定。展开更多
Background Subjective cognitive decline(SCD)is a preclinical stage along the Alzheimer’s disease(AD)continuum.However,little is known about the aberrant patterns of connectivity and topological alterations of the bra...Background Subjective cognitive decline(SCD)is a preclinical stage along the Alzheimer’s disease(AD)continuum.However,little is known about the aberrant patterns of connectivity and topological alterations of the brain functional connectome and their diagnostic value in SCD.Methods Resting-state functional magnetic resonance imaging and graph theory analyses were used to investigate the alterations of the functional connectome in 66 SCD individuals and 64 healthy controls(HC).Pearson correlation analysis was computed to assess the relationships among network metrics,neuropsychological performance and pathological biomarkers.Finally,we used the multiple kernel learning-support vector machine(MKL-SVM)to differentiate the SCD and HC individuals.Results SCD individuals showed higher nodal topological properties(including nodal strength,nodal global efficiency and nodal local efficiency)associated with amyloid-βlevels and memory function than the HC,and these regions were mainly located in the default mode network(DMN).Moreover,increased local and medium-range connectivity mainly between the bilateral parahippocampal gyrus(PHG)and other DMN-related regions was found in SCD individuals compared with HC individuals.These aberrant functional network measures exhibited good classification performance in the differentiation of SCD individuals from HC individuals at an accuracy up to 79.23%.Conclusion The findings of this study provide insight into the compensatory mechanism of the functional connectome underlying SCD.The proposed classification method highlights the potential of connectome-based metrics for the identification of the preclinical stage of AD.展开更多
目的:探讨慢性疼痛患者在全脑磁共振形态学测量(Voxel-based orphometry,VBM)以及脑静息态功能磁共振(resting state fMRI,RS-fMRI)相对于健康人脑部结构与功能方面的影像改变。方法:回顾性分析32例双侧膝骨性关节炎慢性疼痛患者(实验组...目的:探讨慢性疼痛患者在全脑磁共振形态学测量(Voxel-based orphometry,VBM)以及脑静息态功能磁共振(resting state fMRI,RS-fMRI)相对于健康人脑部结构与功能方面的影像改变。方法:回顾性分析32例双侧膝骨性关节炎慢性疼痛患者(实验组)与20例健康志愿者(对照组)VBM及RS-fMRI检查结果,比较VBM、低频振幅(amplitude of spontaneous,ALFF)及功能连接指标。结果:与对照组比较,实验组患者双侧前额叶灰质明显降低,差异具有显著性(P<0.001),脑灰质及白质均未见明显增加或降低,差异无统计学意义(P>0.05);与对照组比较,实验组右侧额上回、右侧额中回、右侧扣带回及右侧岛叶均有显著差异(P<0.001);实验组全脑区均未发现ALFF值明显增加部位;与对照组比较,实验组患者双侧丘脑腹后外侧核(ventral posterolateral nucleus,VPLN)与多个脑区的功能连接存在异常,其中双侧丘脑VPLN与左侧及右侧小脑后叶、中脑和左侧海马功能连接明显增强(P<0.005);双侧丘脑VPLN与双侧前额叶和右侧枕叶功能连接明显减弱(P<0.005)。结论:VBM及RS-fMRI能够准确显示慢性疼痛患者脑区结构以及功能连接改变,临床应用价值较高。展开更多
基金supported by Department of Science and Technology, Zhejiang Province (2015C03037)the National Natural Science Foundation of China (81520108016, 81661148045, 61671198, 81671774, 81701776, 81471653)
文摘Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive neuroscience and clinical studies. A number of comprehensive software packages have been developed for RS-fMRI data analysis, among which a MATLAB package named REST (RESing-state fMRI data analysis Toolkit, released in October 2008 at http://www.restfmri.net)[3] is the earliest one dedicated to RS-fMRI analysis. REST focuses on RS-fMRI postprocessing metrics.
基金This work was supported partly by grants from the National Natural Science Foundation of China(No.81822013,81671665)Jiangsu Provincial Key Medical Talents(No.ZDRCA2016085)+2 种基金the Key Research and Development Program of Jiangsu Province of China(BE2016610)the National Key Research and Development Program of China(2016YFC1300500–504)Jiangsu Province Key Medical Discipline(ZDXKA2016020).
文摘Background Subjective cognitive decline(SCD)is a preclinical stage along the Alzheimer’s disease(AD)continuum.However,little is known about the aberrant patterns of connectivity and topological alterations of the brain functional connectome and their diagnostic value in SCD.Methods Resting-state functional magnetic resonance imaging and graph theory analyses were used to investigate the alterations of the functional connectome in 66 SCD individuals and 64 healthy controls(HC).Pearson correlation analysis was computed to assess the relationships among network metrics,neuropsychological performance and pathological biomarkers.Finally,we used the multiple kernel learning-support vector machine(MKL-SVM)to differentiate the SCD and HC individuals.Results SCD individuals showed higher nodal topological properties(including nodal strength,nodal global efficiency and nodal local efficiency)associated with amyloid-βlevels and memory function than the HC,and these regions were mainly located in the default mode network(DMN).Moreover,increased local and medium-range connectivity mainly between the bilateral parahippocampal gyrus(PHG)and other DMN-related regions was found in SCD individuals compared with HC individuals.These aberrant functional network measures exhibited good classification performance in the differentiation of SCD individuals from HC individuals at an accuracy up to 79.23%.Conclusion The findings of this study provide insight into the compensatory mechanism of the functional connectome underlying SCD.The proposed classification method highlights the potential of connectome-based metrics for the identification of the preclinical stage of AD.
文摘目的:探讨慢性疼痛患者在全脑磁共振形态学测量(Voxel-based orphometry,VBM)以及脑静息态功能磁共振(resting state fMRI,RS-fMRI)相对于健康人脑部结构与功能方面的影像改变。方法:回顾性分析32例双侧膝骨性关节炎慢性疼痛患者(实验组)与20例健康志愿者(对照组)VBM及RS-fMRI检查结果,比较VBM、低频振幅(amplitude of spontaneous,ALFF)及功能连接指标。结果:与对照组比较,实验组患者双侧前额叶灰质明显降低,差异具有显著性(P<0.001),脑灰质及白质均未见明显增加或降低,差异无统计学意义(P>0.05);与对照组比较,实验组右侧额上回、右侧额中回、右侧扣带回及右侧岛叶均有显著差异(P<0.001);实验组全脑区均未发现ALFF值明显增加部位;与对照组比较,实验组患者双侧丘脑腹后外侧核(ventral posterolateral nucleus,VPLN)与多个脑区的功能连接存在异常,其中双侧丘脑VPLN与左侧及右侧小脑后叶、中脑和左侧海马功能连接明显增强(P<0.005);双侧丘脑VPLN与双侧前额叶和右侧枕叶功能连接明显减弱(P<0.005)。结论:VBM及RS-fMRI能够准确显示慢性疼痛患者脑区结构以及功能连接改变,临床应用价值较高。
