摘要
目的:探讨慢性疼痛患者在全脑磁共振形态学测量(Voxel-based orphometry,VBM)以及脑静息态功能磁共振(resting state fMRI,RS-fMRI)相对于健康人脑部结构与功能方面的影像改变。方法:回顾性分析32例双侧膝骨性关节炎慢性疼痛患者(实验组)与20例健康志愿者(对照组)VBM及RS-fMRI检查结果,比较VBM、低频振幅(amplitude of spontaneous,ALFF)及功能连接指标。结果:与对照组比较,实验组患者双侧前额叶灰质明显降低,差异具有显著性(P<0.001),脑灰质及白质均未见明显增加或降低,差异无统计学意义(P>0.05);与对照组比较,实验组右侧额上回、右侧额中回、右侧扣带回及右侧岛叶均有显著差异(P<0.001);实验组全脑区均未发现ALFF值明显增加部位;与对照组比较,实验组患者双侧丘脑腹后外侧核(ventral posterolateral nucleus,VPLN)与多个脑区的功能连接存在异常,其中双侧丘脑VPLN与左侧及右侧小脑后叶、中脑和左侧海马功能连接明显增强(P<0.005);双侧丘脑VPLN与双侧前额叶和右侧枕叶功能连接明显减弱(P<0.005)。结论:VBM及RS-fMRI能够准确显示慢性疼痛患者脑区结构以及功能连接改变,临床应用价值较高。
Objective： to explore the of chronic pain patient with resting state functional mri and eoxel based morphometry. Methods ：32 cases of patients with chronic pain of bilateral knee osteoarthritis and 20 cases of healthy volunteers were researched. The results of VBM and RS-fMRI were compared. Results：The bilateral frontal lobe gray matter of the experiment group were lower than that of the control group（ P 〈 0.00l ） ; There were no significant difference on the ectocinerea and brain white matter（ P 〈 0.001 ） ; The bilateral superior frontal gyms, right middle frontal gyrus, right mediate frontal lobe and isula of the right cerebral of the experiment group were significant difference with the control group（ P 〈 0.001 ） ; There was no increase of ALFF in whole brain area of the experiment group;The two-sided cerebral ganglion VPLN and functional connectivity in multiple regions were abnormal, the two-sided cerebral ganglion VPLN and functional connectivity in multiple regions were enhanced compared with the corltrol group （ P 〈 0. 005 ） ; the two-sided cerebral ganglion VPLN and profrontal lobe and the right side of the occipital lobe were reduced compared with the control group （ P 〈 0. 005 ）. Conclusion：It can show the chronic pain patient with resting state functional mri and coxel based morphometry by VBM and RS-fMRI. It is valuable in clinical application.
出处
《赣南医学院学报》
2014年第1期70-72,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
慢性疼痛
VBM
RS-fMRI
chronic pain
Voxel-based orphornetry
resting state fMRI
