Abstract A transonic, high Reynolds number natural laminar flow airfoil is designed and studied. The γ-θ transition model is combined with the shear stress transport （SST） k-w turbulence model to predict the trans...Abstract A transonic, high Reynolds number natural laminar flow airfoil is designed and studied. The γ-θ transition model is combined with the shear stress transport （SST） k-w turbulence model to predict the transition region for a laminar-turbulent boundary layer. The non-uniform free-form deformation （NFFD） method based on the non-uniform rational B-spline （NURBS） basis function is introduced to the airfoil parameterization. The non-dominated sorting genetic algorithm-II （NSGA-II） is used as the search algo- rithm, and the surrogate model based on the Kriging models is introduced to improve the efficiency of the optimization system. The optimization system is set up based on the above technologies, and the robust design about the uncertainty of the Mach number is carried out for NASA0412 airfoil. The optimized airfoil is analyzed and compared with the original airfoil. The results show that natural laminar flow can be achieved on a supercritical airfoil to improve the aerodynamic characteristic of airfoils.展开更多
目的:研究高血压脑出血患者脑脊液中miR-155(microRNA-155)、miR-126对预后的影响分析。方法:收集2020年1月至2022年12月期间本院收治的129例高血压脑出血患者作为研究对象。根据NIHSS(National Institutes of Health Stroke Scale)评...目的:研究高血压脑出血患者脑脊液中miR-155(microRNA-155)、miR-126对预后的影响分析。方法:收集2020年1月至2022年12月期间本院收治的129例高血压脑出血患者作为研究对象。根据NIHSS(National Institutes of Health Stroke Scale)评分将患者分为重度卒中、中度卒中、轻度卒中三组。收集患者的基线资料。分析对比三组的基线资料。分析入院后第1 d患者miRNA-155和miRNA-126的表达水平,miRNA-155和miRNA-126与血肿量、神经元特异性烯醇化酶(neuron-specific enolase,NSE)、神经纤维丝轻链(Neurofilament light chain,NfL)、NIHSS评分的相关性。分析入院后第14 d患者miRNA-155、miRNA-126与NSE、NfL、APACHE II(Acute Physiology and Chronic Health Evaluation II)评分、mRS(ModifiedRankin Scale)评分、NIHSS评分相关性。绘制ROC(receiver operating characteristic curve)曲线分析miRNA-155、miRNA-126单独及联合用于检测判断脑出血患者预后的价值。结果:重度卒中组中血肿量、合并糖尿病比例、miRNA-155、miRNA-126、NSE、NfL表达水平与其他两组差异具有统计学意义(P<0.05);miRNA-155与血肿量、NSE、NfL表达呈反比,miRNA-126反之(P<0.05)。miRNA-155与NSE、NfL、APACHE II评分呈负相关,miRNA-126反之(P<0.05)。入院14 d联合miRNA-155与miRNA-126对预后预测的敏感度、特异性分别为95.6%、93.2%。结论:入院14 d脑脊液中miRNA-155、miRNA-126在一定程度上反应高血压脑出血患者病情程度,并对患者预后具有一定的临床意义。展开更多
One handled twenty- one cases of nasal and naso-pharyngeal lymphoma were analyzed in this paper. These cases were divided macroscopically Into 4 main types Including giant mass type, nodular type, thickbulgy type and ...One handled twenty- one cases of nasal and naso-pharyngeal lymphoma were analyzed in this paper. These cases were divided macroscopically Into 4 main types Including giant mass type, nodular type, thickbulgy type and ulcerating type. Microscopic histologic varieties were classified to non-Hodgkin' s lymphoma (NHL) and Hodg-Kin' s disease (HD).Differential diagnosis between NPL and nasopharyngeal carcinoma (NPC) and the problem how to ascertain the primary and secondary tumors were discussed.展开更多
A multiple classifier fusion approach based on evidence combination is proposed in this paper. The individual classifier is designed based on a refined Nearest Feature Line (NFL),which is called Center-based Nearest N...A multiple classifier fusion approach based on evidence combination is proposed in this paper. The individual classifier is designed based on a refined Nearest Feature Line (NFL),which is called Center-based Nearest Neighbor (CNN). CNN retains the advantages of NFL while it has relatively low computational cost. Different member classifiers are trained based on different feature spaces respectively. Corresponding mass functions can be generated based on proposed mass function determination approach. The classification decision can be made based on the combined evidence and better classification performance can be expected. Experimental results on face recognition provided verify that the new approach is rational and effective.展开更多
Background Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders.In this study,we aimed to investigate the distribution of neurofilaments...Background Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders.In this study,we aimed to investigate the distribution of neurofilaments in the cerebral cortex of Parkinson’s disease(PD),PD with dementia(PDD)and dementia with Lewy bodies(DLB)donors,and its association with pathology load and MRI measures of atrophy and diffusivity.Methods Using a within-subject post-mortem MRI-pathology approach,we included 9 PD,12 PDD/DLB and 18 age-matched control donors.Cortical thickness and mean diffusivity(MD)metrics were extracted respectively from 3DT1 and DTI at 3T in-situ MRI.After autopsy,pathological hallmarks(pSer129-αSyn,p-tau and amyloid-βload)together with neurofilament light-chain(NfL)and phosphorylated-neurofilament medium-and heavy-chain(p-NfM/H)immunoreactivity were quantified in seven cortical regions,and studied in detail with confocal-laser scanning microscopy.The correlations between MRI and pathological measures were studied using linear mixed models.Results Compared to controls,p-NfM/H immunoreactivity was increased in all cortical regions in PD and PDD/DLB,whereas NfL immunoreactivity was increased in the parahippocampal and entorhinal cortex in PDD/DLB.NfL-positive neurons showed degenerative morphological features and axonal fragmentation.The increased p-NfM/H correlated with p-tau load,and NfL correlated with pSer129-αSyn but more strongly with p-tau load in PDD/DLB.Lastly,neuro-filament immunoreactivity correlated with cortical thinning in PD and with increased cortical MD in PDD/DLB.Conclusions Taken together,increased neurofilament immunoreactivity suggests underlying axonal injury and neurofilament accumulation in morphologically altered neurons with increased pathological burden.Importantly,we demonstrate that such neurofilament markers at least partly explain MRI measures that are associated with the neurodegenerative process.展开更多
Graphene is a material composed of a single layer of carbon atoms arranged in a two-dimensional honeycomb lattice. The unique elec- trical, optical, thermal, and mechanical properties of graphene are extensively explo...Graphene is a material composed of a single layer of carbon atoms arranged in a two-dimensional honeycomb lattice. The unique elec- trical, optical, thermal, and mechanical properties of graphene are extensively exploited for various applications in electronics, energy, and sensors.展开更多
文摘Abstract A transonic, high Reynolds number natural laminar flow airfoil is designed and studied. The γ-θ transition model is combined with the shear stress transport （SST） k-w turbulence model to predict the transition region for a laminar-turbulent boundary layer. The non-uniform free-form deformation （NFFD） method based on the non-uniform rational B-spline （NURBS） basis function is introduced to the airfoil parameterization. The non-dominated sorting genetic algorithm-II （NSGA-II） is used as the search algo- rithm, and the surrogate model based on the Kriging models is introduced to improve the efficiency of the optimization system. The optimization system is set up based on the above technologies, and the robust design about the uncertainty of the Mach number is carried out for NASA0412 airfoil. The optimized airfoil is analyzed and compared with the original airfoil. The results show that natural laminar flow can be achieved on a supercritical airfoil to improve the aerodynamic characteristic of airfoils.
文摘One handled twenty- one cases of nasal and naso-pharyngeal lymphoma were analyzed in this paper. These cases were divided macroscopically Into 4 main types Including giant mass type, nodular type, thickbulgy type and ulcerating type. Microscopic histologic varieties were classified to non-Hodgkin' s lymphoma (NHL) and Hodg-Kin' s disease (HD).Differential diagnosis between NPL and nasopharyngeal carcinoma (NPC) and the problem how to ascertain the primary and secondary tumors were discussed.
基金Supported by Grant for State Key Program for Basic Research of China (973) (No. 2007CB311006)
文摘A multiple classifier fusion approach based on evidence combination is proposed in this paper. The individual classifier is designed based on a refined Nearest Feature Line (NFL),which is called Center-based Nearest Neighbor (CNN). CNN retains the advantages of NFL while it has relatively low computational cost. Different member classifiers are trained based on different feature spaces respectively. Corresponding mass functions can be generated based on proposed mass function determination approach. The classification decision can be made based on the combined evidence and better classification performance can be expected. Experimental results on face recognition provided verify that the new approach is rational and effective.
基金funded by The Michael J.Fox Foundation(grant#17253)Stichting ParkinsonFonds(grant#1881)supported by the NIHR biomedical research centre at the University College Hospital of London(UCLH).
文摘Background Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders.In this study,we aimed to investigate the distribution of neurofilaments in the cerebral cortex of Parkinson’s disease(PD),PD with dementia(PDD)and dementia with Lewy bodies(DLB)donors,and its association with pathology load and MRI measures of atrophy and diffusivity.Methods Using a within-subject post-mortem MRI-pathology approach,we included 9 PD,12 PDD/DLB and 18 age-matched control donors.Cortical thickness and mean diffusivity(MD)metrics were extracted respectively from 3DT1 and DTI at 3T in-situ MRI.After autopsy,pathological hallmarks(pSer129-αSyn,p-tau and amyloid-βload)together with neurofilament light-chain(NfL)and phosphorylated-neurofilament medium-and heavy-chain(p-NfM/H)immunoreactivity were quantified in seven cortical regions,and studied in detail with confocal-laser scanning microscopy.The correlations between MRI and pathological measures were studied using linear mixed models.Results Compared to controls,p-NfM/H immunoreactivity was increased in all cortical regions in PD and PDD/DLB,whereas NfL immunoreactivity was increased in the parahippocampal and entorhinal cortex in PDD/DLB.NfL-positive neurons showed degenerative morphological features and axonal fragmentation.The increased p-NfM/H correlated with p-tau load,and NfL correlated with pSer129-αSyn but more strongly with p-tau load in PDD/DLB.Lastly,neuro-filament immunoreactivity correlated with cortical thinning in PD and with increased cortical MD in PDD/DLB.Conclusions Taken together,increased neurofilament immunoreactivity suggests underlying axonal injury and neurofilament accumulation in morphologically altered neurons with increased pathological burden.Importantly,we demonstrate that such neurofilament markers at least partly explain MRI measures that are associated with the neurodegenerative process.
基金supported by the National Science Foundation(NSF)Graduate Research Fellowship 1610400(to TB)NSF through the Nebraska Materials Research Science and Engineering Center(MRSEC)+4 种基金DMR-1420645(all to AS)Nebraska Research Initiative(to AS and JYL)NSF CAREER Award 1351570Nebraska Department of Health and Human Services Stem Cell Research Project 2015-06Nebraska Tobacco Settlement Biomedical Research Seed Grant(all to JYL)
文摘Graphene is a material composed of a single layer of carbon atoms arranged in a two-dimensional honeycomb lattice. The unique elec- trical, optical, thermal, and mechanical properties of graphene are extensively exploited for various applications in electronics, energy, and sensors.
