摘要
本实验在经口增加SD大鼠体内铝负荷后,动态观察了体重、全血及骨铝含量的变化,血清和骨组织提取液的碱性磷酸酶(AKP)活性及钙、磷含量的变化。结果发现铝可经消化道吸收、使大鼠生长发育明显延缓(P<0.05～P<0.01),使血液和骨组织内铝含量明显增加(P<0.05～P<0.01),引起血清和骨组织钙、磷含量显著下降(P<0.05～P<0.01),但对AKP活性抑制不明显。提示铝对大鼠骨代谢具有毒性作用,铝可能通过干扰钙、磷代谢而影响骨生长。
In this experiment, Sprague-Dawley rats were given Aluminum loded water (1% AlCl_3·6H_2O) and food (2% AlCl_3·6H_2O) in place of their usual drinking water and food. The changes of the body weights and those of Al, AKP, Ca and phosphate of serum and bone were investigated. The results indicated that Al can be absorbed through alimentary canal, causing increase of serum and bone Al (P<0.05～P<0.01)but decrease of serum and bone Ca and phosphate(P<0.05～P<0.01). The inhibitions of AKP activites in serum and bone tissue were not significant. The development and growth of rats were retarded by Al (P<0.05～P<0.01). These results suggest that AlCl_3 have poisoning effects on the bone metabolism of rats. AlCl_3 may stunt the bone growth by the metabolic disturbance of Ca and phosppahte.
出处
《安徽医科大学学报》
CAS
1993年第1期23-25,共3页
Acta Universitatis Medicinalis Anhui
关键词
血液
碱性磷酸酶
氯化铝
aluminum
bone
blood
clacium
phosphats
alkaline phosphatase
rat
