摘要
目的了解贵州省地方性氟中毒病区骨软化畸形儿童尿和头发中氟、铝含量及骨组织形态计量学特点。方法采集14例骨软化畸形(病例组)和7例正常儿童(对照组)尿和头发样本检测氟、铝等元素。同时取2例骨软化儿童和2例正常儿童髂前上棘处少量骨骼进行不脱钙骨制片及骨形态计量学观察。结果病例组尿氟、尿铝、发铝水平分别是对照组的2.46、2.39、3.17倍,差异均有统计学意义(P<0.05)。病例组的骨组织形态学观察发现骨小梁胶原纤维排列紊乱,骨内出现软骨细胞,小梁边缘大量类骨质,且其周长和面积参数明显增加,骨吸收陷窝明显增加。结论贵州省地方性骨软化畸形儿童主要是氟铝联合中毒,骨组织形态学特点是骨矿化障碍、骨吸收增加。
Objective To determine urine and hair levels of fluorine and aluminum and bone histomorphometry in endemic osteomalacia children in Guizhou province. Methods Urine and hair levels of fluorine, aluminum and so on were detected in 14 osteomalacia and 7 normal children, and bone histomorphometry of the anterior superior iliac spine was done in 2 osteomalacia and 2 normal children. Results Urine fluorine, and urine and hair aluminum contents in patients were 2.46, 2.39 and 3.17 times respectively compared with controls （P〈0.05）. The bone histomorphometry of osteomalacia children showed the derangement of trabecular collagen fibers, chondrocytes within bone, massive osteoids around trabeculae, increased osteoid perimeter and area, and elevated lacunar resorption. Conclusion The children with endemic osteomalacia in Guizhou present with fluorine and aluminum poisoning, and the characteristics of bone histomorphometry are disordered bone mineralization and increased resorption.
出处
《广东医学院学报》
2012年第5期488-491,共4页
Journal of Guangdong Medical College
关键词
骨软化
铝氟联合中毒
儿童
骨组织形态计量学
osteomalacia
fluorine and aluminum poisoning
children
bone histomorphometry
