摘要
目的:探讨大肠癌组织中血管内皮生长因子-C(VEGF-C)的表达及其与临床病理指标和预后的关系. 方法:应用免疫组化SP法检测96例大肠癌组织中VEGF- C的表达,并分析其与大肠癌临床病理指标和预后的关系. 结果:大肠癌组织VEGF-C阳性率明显高于正常大肠组织(42/96 vs 19/96,P<0.01);大肠癌VEGF-C表达与大肠癌分化程度、Dukes分期、淋巴结转移及患者预后密切相关(P<0.01或P<0.05),但是与患者年龄、性别、肿瘤大小、部位、浸润深度以及远处器官转移无关(P>0.05).41 例有淋巴结转移病例的转移灶和原发灶癌组织的VEGF-C 表达相当一致(P<0.01). 结论:VEGF-C可能通过诱导淋巴管生成促进大肠癌淋巴结转移,并且可以作为指导大肠癌治疗和判断预后的一个重要指标.
AIM: To explore the expression of endothelial growth factors C (VEGF-C) in large intestine carcinoma, and its relationship to clinicopathological features and prognosis. METHODS: The expression of VEGF-C in 96 cases of large intestine carcinoma was detected by SP immunohistochemical technique and its relationship to clinicopathological features and prognosis were analysed. RESULTS: The expression of VEGF-C was significantly higher in intratumoral tissue than that in normal mucosa (42/96 vs 19/96, P<0.01). VEGF-C positive expression was significantly correlated with tumor differentiation, Dukes' stage, lymph node metastasis and prognosis in 96 cases of large intestine carcinoma (P<0.01 or P<0.05), but its relationship to age and gender of patient, size, site and depth of invasion of tumour and organ metastasis was not found (P>0.05). The expression of VEGF-C in metastatic lymph nodes was fairly consistent with that in the primary tumour(P<0.01). CONCLUSION: The overexpression of VEGF-C in large intestine carcinoma can develop lymph node metastasis by inducing lymphangiogenesis, and it may serve as one prognostic factor and guide the treatment.
出处
《世界华人消化杂志》
CAS
2004年第5期1061-1064,共4页
World Chinese Journal of Digestology
