摘要
目的 :探讨凋亡抑制蛋白survivin和环氧化酶 2(COX 2 )在胰腺癌组织中的表达与生物学行为之间的关系及二者的相关性 .方法 :用免疫组织化学Envision法对 5 1例胰腺导管癌survivin和COX 2的表达进行检测 .结果 :5 1例胰腺导管癌中survivin蛋白和COX 2蛋白的表达率分别为 80 .4 %和 74 .5 % ;两者在 1 1例癌旁非肿瘤胰腺组织中均未发现阳性表达 .Survivin的表达与组织学分级有关 (P <0 .0 1 ) ,而与临床分期和淋巴结转移关系不大 (P >0 .0 5 ) ;COX 2的表达与临床分期、淋巴结转移有关 (P≤ 0 .0 5 ) ,而与组织学分级关系不大 (P >0 .0 5 ) ;survivin的表达与COX 2的表达密切相关 (P<0 .0 5 ) .两者的表达与患者的性别、年龄、肿瘤的大小、部位均无关 .结论 :Survivin和COX 2密切相关 ,可能在胰腺癌的发生、发展过程中起关键作用 ,可能为胰腺癌的治疗提供了新的靶点 .
AIM: To investigate correlation of the expression of survivin and cyclooxygenase 2 (COX 2) and the clinicobiological behavior in human pancreatic adenocarcinoma tissues. METHODS: The expressions of survivin and COX 2 in 51 cases of human pancreatic ductal adenocarcinoma were detected with immunohistochemistry of Envision. RESULTS: The expression rates of survivin and COX 2 in pancreatic ductal adenocarcinoma were 80.4% and 74.5%, respectively, and no expression of survivin and COX 2 in the 11 cases of adjacent normal tissues was found. The survivin expression was significantly correlated with the histological grade ( P <0.01), but not with the clinical stages and lymph node metastasis status ( P >0.05). The COX 2 expression was significantly correlated with the clinical stages and lymph node metastasis status ( P ≤ 0.05) but not with the histological grades ( P >0.05). The expression of surviving and COX 2 had no correlation with age, sex, tumor size and location but the expression of survivin was closely correlated with that of COX 2 ( P <0.05). CONCLUSION: The intimate relation of survivin and COX 2 may play an important role in the tumorigenesis and tumor progression in pancreatic cancer, and they may provide some new targets for the therapy of pancreatic cancer.
出处
《第四军医大学学报》
北大核心
2004年第7期635-636,共2页
Journal of the Fourth Military Medical University
关键词
胰腺肿瘤
存活素
环氧化酶-2
凋亡
pancreatic neoplasms
survivin
cyclooxygenase 2
apoptosis
