摘要
目的 为了观察日照市不同地区人群HBV标志物的变化趋势。方法 采用单纯随机抽样的方法对该市东港区405名不同年龄人群进行了调查,采静脉血2 ml,用ELA法检测HBsAg和抗-HBs。结果 HB-sAg平均携带率为2.96％,20-40岁组最高为5.46％,其他各年龄组之间无显著差异。抗-HBs平均阳性率为60.99％,<2岁最高为81.54％,8岁组最低为41.67％,二者之间有显著统计学意义,但HBsAg携带率无差异,有乙肝疫苗免疫史抗-HBs阳性率为62.50％,无免疫史者抗-HBs阳性率为36.07％。结论 接种乙肝疫苗是预防乙型肝炎最有效的措施,但接种乙肝4年后抗-HBs阳性率迅速下降,通过加强免疫抗-HBs可迅速提高。如果从提高抗-HBs阳性率的角度考虑,在新生儿全程接种乙肝疫苗5年后,对抗-HBs阴性者有必要进行加强免疫。在免疫后的10年内无需普遍实施加强免疫。
Objective To explore the HBV mark’s changing tendence in Rizhao City.Method To
adopt the simple random sampling method to investigate 405 persons of different age in Donggang district;
and to collect 2 ml of vein blood to examine HBsAg and anti-HBs with ELA method.Results The average
rate of HBsAg carrying was 2.96%,and the highest rate of HBsAg crrying was in the group of 20-40 years
old(5.46%).There were no significant different among other groups.Meanwhile,the average positive rate
of anti-HBs、was 60.99%,the highest positve rate was in the group of<2 years old(81.54%),and the
lowest positive rate was in the group of 8 years old.There was a statistical significant different between them.
In people Who had HBV vaccine immunity experience,the positive rate of anti- HBs was 62.50%,and in
those who hadn't HBV vaccine immunity experience was 36.07%.Conclusions The inoculability of HBV
vaccine was proved to be efficacious against HBV,but positive rate of anti- HBs declined rapidly after 4 years
of HBV vaccine inoculability.In order to improve the positive rate of anti-HBe,it was necessary to augment
immunity to neonates who were negative of anti- HBs after 5 years of the whole course of HBV vaccine in-
ocubaity.Otheriwise,it wasn't necessary to apply augmenting immunity after 10 years.
出处
《疾病监测》
CAS
2004年第4期125-126,共2页
Disease Surveillance
