摘要
目的分析乙型肝炎病毒(HBV)标志物检测模式在人群中的分布并初步探询其流行病学意义。方法用酶联免疫法(ELISA)对本院2007年5月至2008年4月间免疫室12204例血液样标本进行HBV标志物测定。结果乙肝病毒表面抗原(HBsAg)阳性标本中,出现4种常见模式,以HBsAg、抗-HBe、抗-HBc3种阳性(俗称"小三阳")所占比例最大(53.9%),尤其在20岁以上年龄组中最为明显(占所有"小三阳"的92.9%)。而HBsAg阴性标本中出现6种常见模式,以5项全阴性和仅抗-HBs阳性最常见(分别占47.8%和47.9%),其余模式均占较小比率。结论"小三阳"是HBV在体内转为慢性感染较为稳定的模式,随年龄的增大这种模式所占的百分比率显著增加;各年龄组仍有相当一部分人群对HBV缺乏有效的抵抗力,急需要接种或加强接种乙肝疫苗,尤其要重视20岁以上的人群,从而有效防止HBV的传播。
Objective To analyze the distribution of detected model of the markers for hepatitis B virus and explore its epidemiological significance preliminarily. Methods The markers of hepatitis B virus of 12,204 cases were detected by ELISA method from May 2007 to April 2008. Results 4 routing HBV infected models were detected from the patients of HBsAg positive. HBsAg, HBeAb,and HBcAb positive （commonly known as small three positives）was the most common one. Its percentage was 53.9% among all HBV infected persons, and among all small three positive,especially among the goroup of patients over the age of 20,the percentage was 92.9%. While six routing HBV markers models were detected from the persons of HBsAg negative. Most common models were five makers negative and HBsAb positive only,which accounts for 47.8% and 47.9% respectively. Conclusion Small three positive was one of the stable models in HBV infected group. And the percentage of those models obviously increased along with the increase of the age; Various age groups still had a consiclerable number of person living on the lack of effective resistant to hepatitis B virus, who need to be vaccinated or strengthen the vaccination to hepatitis B virus urgently. Particular emphasis should be put on the people over the age of 20,so the spread of hepatitis B virus could be prevented effectively.
出处
《检验医学与临床》
CAS
2010年第5期398-399,共2页
Laboratory Medicine and Clinic
